首页|Quantitative detection of citrate for early stage diagnosing of prostate cancer:Discriminating normal to cancer in prostate tissues

Quantitative detection of citrate for early stage diagnosing of prostate cancer:Discriminating normal to cancer in prostate tissues

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Prostate cancer(PC)biomarker-citrate detection is clinically important to diagnose PC in early stages.Methylquinolinium iodide(Q)conjugated indole-phenylboronic acid(IB)was designed as a red-emissive QIB probe for the detection of citrate through Lewis acid-base reaction and intramolecular charge transfer(ICT)sensing mechanisms.Boronic acid acts as Lewis acid as well as citrate(Lewis base)recognition unit.The probe reacted with citrate,showing enhanced red emissions.Since the probe has excellent water solubility and great biocompatibility,practical application in biological systems is possible.Citrate was monitored precisely in the mitochondria organelle(in vitro)of living cells with a positive charge on QIB.Also,endogenous(in situ)citrate was detected quantitatively to discriminate non-cancerous and PC mice,observed strong and lower(negligible)emission intensity on non-cancerous and cancerous prostate tissues,respectively.Because,the concentration of citrate is higher in healthy prostate compared with PC prostate.Furthermore,the analysis of sliced prostate tissues can give PC-related information for clinical diagnosis to prevent and treat PC in the initial stages.Therefore,we believe that the present probe is a promising biochemical reagent in diagnosing PC.

Prostate cancerBiomarker-citrateBoronic acidLewis acid/base-ICTRed-emissiveMitochondria targetingProstate tissue

Selvaraj Muthusamy、Kanagaraj Rajalakshmi、Palanisamy Kannan、Yun-Sik Nam、Dongwei Zhu、Yeonggil Seo、Jong-Won Song、Dong Nyoung Heo、Il Keun Kwon、Yuanguo Xu

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School of Chemistry and Chemical Engineering,Jiangsu University,Zhenjiang 212013,China

College of Biological,Chemical Sciences and Engineering,Jiaxing University,Jiaxing 314001,China

Advanced Analysis Center,Korea Institute of Science & Technology,Seongbuk-gu,Seoul 02792,Republic of Korea

School of Medicine,Jiangsu University,Zhenjiang 212013,China

Department of Chemistry Education,Daegu University,Gyeongsan-si,Gyeongsangbuk-do 38453,Republic of Korea

Department of Dental Materials,School of Dentistry,Kyung Hee University,Seoul,Republic of Korea

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国家自然科学基金Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT &

221504103272020R1A2C1102741

2024

10.1016/j.cclet.2023.108880

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(2)
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