Abstract
Photodynamic therapy(PDT)is an effective treatment method for tumors.But the specifically accumu-lated of photosensitizer was very difficult in the tumor site,which greatly limited the efficacy of PDT.Here,mitochondria-targeted Janus mesoporous nanoplatform(JPMO-Pt-CTPP-ZnPc)for PDT was prepared,the nanoplatform has uniform size(275 nm)and good dispersion and biocompatibility.The confocal laser scanning microscopy(CLSM)revealed the signal of ZnPc of JPMO-Pt-CTPP-ZnPc were higher than JPMO-Pt-ZnPc in tumor cells,and flow cytometry results showed the cell uptake efficiency of JPMO-Pt-CTPP-ZnPc was 2.5-fold higher than that of JPMO-Pt-ZnPc.This revealed the modification of CTPP significantly improves the targeting ability of the nanoplatform.In vitro anti-tumor experiment showed the JPMO-Pt-CTPP-ZnPc significantly inhibited the growth of tumor cells upon the irradiation of low-power laser,and the survival rate of cells incubated with 60 μg/mL JPMO-Pt-CTPP-ZnPc was only 3％.Simultaneously,com-pared with JPMO-Pt-ZnPc(not modified with mitochondria targeting molecules CTPP),the PDT efficacy of JPMO-Pt-CTPP-ZnPc was significantly better,as it has targeted mitochondria in cells.
基金项目
国家自然科学基金(81971675)
国家自然科学基金(22275099)
Project of State Key Laboratory of Organic Electronics and Information Displays,Nanjing University of Posts & Telecommunications(GDX2022010014)
Natural Science Research Start up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(NY222067)
维普
万方数据