Mitochondria-targeted Janus mesoporous nanoplatform for tumor photodynamic therapy

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外文摘要：Photodynamic therapy(PDT)is an effective treatment method for tumors.But the specifically accumu-lated of photosensitizer was very difficult in the tumor site,which greatly limited the efficacy of PDT.Here,mitochondria-targeted Janus mesoporous nanoplatform(JPMO-Pt-CTPP-ZnPc)for PDT was prepared,the nanoplatform has uniform size(275 nm)and good dispersion and biocompatibility.The confocal laser scanning microscopy(CLSM)revealed the signal of ZnPc of JPMO-Pt-CTPP-ZnPc were higher than JPMO-Pt-ZnPc in tumor cells,and flow cytometry results showed the cell uptake efficiency of JPMO-Pt-CTPP-ZnPc was 2.5-fold higher than that of JPMO-Pt-ZnPc.This revealed the modification of CTPP significantly improves the targeting ability of the nanoplatform.In vitro anti-tumor experiment showed the JPMO-Pt-CTPP-ZnPc significantly inhibited the growth of tumor cells upon the irradiation of low-power laser,and the survival rate of cells incubated with 60 μg/mL JPMO-Pt-CTPP-ZnPc was only 3％.Simultaneously,com-pared with JPMO-Pt-ZnPc(not modified with mitochondria targeting molecules CTPP),the PDT efficacy of JPMO-Pt-CTPP-ZnPc was significantly better,as it has targeted mitochondria in cells.

外文关键词：

Mesoporous materialsJanus particlePhotodynamic therapyMitochondria targetingTumor treatment

作者：

Min Dong、Rui Tang、Jing Li、Jiajia Zhao、Yu Wang、Lin Ouyang、Wei Lu、Jun Tao、Meng Dang、Yuxia Tang、Zhaogang Teng

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作者单位：

Key Laboratory for Organic Electronics & Information Displays and Jiangsu Key Laboratory for Biosensors,Institute of Advanced Materials,Jiangsu National Synergetic Innovation Centre for Advanced Materials,Nanjing University of Post and Telecommunications,Nanjing 210023,China

Department of Radiology,The 909th Hospital,Southeast Hospital,School of Medicine,Xiamen University,Zhangzhou 363000,China

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Institute of Functional Materials,Donghua University,Shanghai 201620,China

Laboratory of Molecular Imaging,Department of Radiology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China

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基金：

国家自然科学基金国家自然科学基金Project of State Key Laboratory of Organic Electronics and Information Displays,Nanjing University of Posts & TelecommunicationsNatural Science Research Start up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications

项目编号：

8197167522275099GDX2022010014NY222067

出版年：

2024

DOI：

10.1016/j.cclet.2023.108539

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(2)

参考文献量40