首页|Deciphering the high-carbonization-temperature triggered enzymatic activity of wool-derived N,S-co-doped carbon nanosheets

Deciphering the high-carbonization-temperature triggered enzymatic activity of wool-derived N,S-co-doped carbon nanosheets

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It is well-established that high carbonization temperature will trigger the enzyme-like activity of carbon-based materials.However,the catalytic mechanism is still ambiguous,which hinders the further rational design of nanomaterials as enzyme mimics.Hereby,N,S-rich carbonized wool nanosheets(CWs)were synthesized at different pyrolysis temperatures.As expected,only CWs treated with high-temperature possess intrinsic oxidase-and peroxidase-like activities.Meanwhile,density functional theory(DFT)cal-culations demonstrate that graphitic nitrogen and the co-existence of nitrogen and sulfur in the carbon matrix serve as the active sites for the enzyme-like process.More importantly,combining theoretical calculations and experimental observations,the high-temperature triggered catalytic mechanism can be ascribed to the fact that an appropriate high-temperature maximizes the graphitization degree to a cer-tain extent,at which most of the catalytic active sites are well retained rather than evaporating.More-over,coupling with excellent photothermal conversion efficiency and catalytic performance,CWs can be applied to photothermal-catalytic cancer therapy under near-infrared region(NIR)light irradiation.We believe this work will contribute to understanding the catalytic mechanism of carbon-based nanozymes and promote the development of new biomedical and pharmaceutical applications.

Carbon-based nanozymeCatalytic mechanismDensity functional theoryHigh-temperature carbonization

Jiachen Zhao、Deshuai Yu、Jianmin Chen、Shihao Lin、Yonghua Tang、Chaoyu Fan、Dongfang Zhou、Youhui Lin

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Department of Physics,Research Institute for Biomimetics and Soft Matter,Fujian Provincial Key Laboratory for Soft Functional Materials Research,Xiamen University,Xiamen 361005,China

School of Pharmacy and Medical Technology,Putian University,Putian 351100,China

Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine(Putian University),Fujian Province University,Putian 351100,China

Key Laboratory of Mental Health of the Ministry of Education,NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China

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国家自然科学基金国家自然科学基金Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine(Putian University)Fujian Province University中央高校基本科研业务费专项高等学校学科创新引智计划(111计划)

1227435622275081PALM 20220620720220022B16029

2024

10.1016/j.cclet.2023.109080

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(3)
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