首页|Ultrastable graphene isolated AuAg nanoalloy for SERS biosensing and photothermal therapy of bacterial infection
Ultrastable graphene isolated AuAg nanoalloy for SERS biosensing and photothermal therapy of bacterial infection
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Plasmonic metal nanomaterials with intrinsic surface-enhanced Raman scattering(SERS)and photother-mal properties,especially AuAg nanoalloys with both the outstanding merits of Au and Ag nanocrystals,show huge application prospects in bacterial theranostics.However,the direct exposure of AuAg nanoal-loys in external conditions probably cause undesirable reactions and poisonous metal ion leakage during SERS detection and photothermal antibacterial therapy process,which severely hinder bacterial theranos-tics applications.Herein,we report an ultrastable graphene-isolated AuAg nanoalloy(GAA)with AuAg core confined in few-layer graphitic shell as a versatile platform for bacterial detection and therapy.The encapsulation of graphene ensures the good stability of AuAg core,that its superior SERS and photother-mal properties are therefore further guaranteed.GAA is used for SERS detection of two vital bacterial biomarkers(including corrosive cyanide and pyocyanin),exhibiting good SERS quantitative and multi-plexing ability.GAA is further used for photothermal antibacterial therapy application,and ultrahigh an-tibacterial efficacies for both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus are achieved under 808 nm laser irradiation.This work proposes a valuable method to develop robust bacte-rial theranostic platform.
Molecular Science and Biomedicine Laboratory(MBL),State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,College of Biology,Aptamer Engineering Center of Hunan Province,Hunan University,Changsha 410082,China
School of Chemistry and Chemical Engineering/Guangzhou Key Laboratory for Clean Energy and Materials/Key Laboratory for Water Quality and Conservation of the Pearl River Delta,Ministry of Education,Guangzhou University,Guangzhou 510006,China
国家重点研发计划国家重点研发计划国家自然科学基金Science and Technology Innovation Program of Hunan Province中国博士后科学基金
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