Abstract
Plasmonic metal nanomaterials with intrinsic surface-enhanced Raman scattering(SERS)and photother-mal properties,especially AuAg nanoalloys with both the outstanding merits of Au and Ag nanocrystals,show huge application prospects in bacterial theranostics.However,the direct exposure of AuAg nanoal-loys in external conditions probably cause undesirable reactions and poisonous metal ion leakage during SERS detection and photothermal antibacterial therapy process,which severely hinder bacterial theranos-tics applications.Herein,we report an ultrastable graphene-isolated AuAg nanoalloy(GAA)with AuAg core confined in few-layer graphitic shell as a versatile platform for bacterial detection and therapy.The encapsulation of graphene ensures the good stability of AuAg core,that its superior SERS and photother-mal properties are therefore further guaranteed.GAA is used for SERS detection of two vital bacterial biomarkers(including corrosive cyanide and pyocyanin),exhibiting good SERS quantitative and multi-plexing ability.GAA is further used for photothermal antibacterial therapy application,and ultrahigh an-tibacterial efficacies for both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus are achieved under 808 nm laser irradiation.This work proposes a valuable method to develop robust bacte-rial theranostic platform.
基金项目
国家重点研发计划(2022YFC2403501)
国家重点研发计划(2020YFA0210800)
国家自然科学基金(22225401)
Science and Technology Innovation Program of Hunan Province(2020RC4017)
中国博士后科学基金(2021M701145)
NETL
NSTL
万方数据