Abstract
Here,we report a concise and divergent enantioselective total synthesis of marine sesquiterpene quinone meroterpenoids(+)-dysidavarones A-C(1-3)using predysidavarone 6 as a key common intermediate.The highly strained and bridged eight-membered carbocycle of predysidavarone 6 was constructed by a one-pot intermolecular alkylation and intramolecular arylation of Wieland-Miescher ketone derivative 11 and benzyl bromide 12.The total synthesis of(+)-dysidavarones A-C(1-3)was achieved from predysi-davarone 6 in a divergent manner by a late-stage introduction of the ethoxy group,which reveals the possible source of the ethoxy group within(+)-dysidavarones A-C(1-3)and provides a late-stage modi-fiable route for the synthesis of dysidavarone analogs for further anti-cancer activity evaluation.
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