首页|Copper-catalyzed conjugate addition of allene-derived nucleophiles to alkenyl-substituted carboxamides
Copper-catalyzed conjugate addition of allene-derived nucleophiles to alkenyl-substituted carboxamides
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Catalytic Michael addition reaction represents a fundamental importance in organic synthetic chem-istry.Whereas corresponding conversions toward intrinsically low reactive enamide remains an ongoing challenging.We herein report a copper-catalyzed conjugate addition of allenes to β-substituted alkenyl amides,one of the most challenging Michael acceptors.The present method utilizes readily available al-lenes as the latent carbon-based nucleophiles and simple,common β-substituted alkenyl amides as start-ing materials,unlike previous methods that usually preinstall an activating group to improve the reac-tivity of amide or uses highly reactive stoichiometric quantities of organometallics.Hence,this approach shows good functional group compatibility and can be implemented under mild reaction conditions with excellent level of chemo-and regioselectivities.
Bin Fu、Yue Zhao、Xiuping Yuan、Yanfei Li、Jianjun Yin、Simin Wang、Tao Xiong、Qian Zhang
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Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis,Department of Chemistry,Northeast Normal University,Changchun 130024,China
School of Chemistry and Environmental Engineering,Changchun University of Science and Technology,Changchun 130012,China
State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China
国家自然科学基金国家自然科学基金国家自然科学基金Jilin Province Natural science Foundation中央高校基本科研业务费专项Ten Thousand Talents Program
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