首页|Development of a cell-permeable adenine-derived probe for capture of nucleotide-binding proteins in living cells

Development of a cell-permeable adenine-derived probe for capture of nucleotide-binding proteins in living cells

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Adenine is an essential building block of genetic material and a range of coenzymes.Chemical probes containing an adenine moiety have been used in kinase profiling studies in cell lysates.Here we report that adenine-derived small-molecule probes with an activated ester reactive group can covalently modify a conserved lysine residue of protein kinases and capture a number of nucleotide-binding proteins within living cells.

Adenine-derived probeCell-permeableLysine residueProtein kinasesNucleotide-binding proteins

Lihong Liu、Rui Chen、Gang Xue、Chenzhou Hao、Weizhi Weng、Zhengying Pan

展开 >

State Key Laboratory of Chemical Oncogenomics,School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen 518055,China

国家自然科学基金Shenzhen Science and Technology Innovation CommissionShenzhen Science and Technology Innovation Commission北京大学项目

8187274920200815000631001JCYJ20200109120414564

2024

10.1016/j.cclet.2023.108455

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(3)
  • 25