Copper(Ⅰ)-catalyzed interrupted click/radical relay:A four-component modular synthesis of triazole sulfones

Pengfei Sun ¹Fang Wei ²Chen-Ho Tung ¹Zhenghu Xu³

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作者信息

1. Key Lab for Colloid and Interface Chemistry of Education Ministry,Shandong University,Ji'nan 250100,China
2. Key Laboratory of Organic Chemistry in Jiangxi Province,Institute of Organic Chemistry,Jiangxi Science & Technology Normal University,Nanchang 330013,China
3. Key Lab for Colloid and Interface Chemistry of Education Ministry,Shandong University,Ji'nan 250100,China;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China;Functional Molecules of Zhejiang Province,School of Science,Westlake University,Hangzhou 310024,China
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Abstract

A new,four component copper(l)-catalyzed interrupted click/radical relay cascade has been developed.This unprecedented interrupted click reaction provides a rapid modular synthesis of triazole sulfones,important privileged heterocyclic pharmacophores which cannot be accessed by a traditional click reac-tion.Radical interception of cuprate-triazole,the key reaction intermediate formed in situ,is an important feature of this process.

Key words

Click reaction/Triazole/Sulfone/Radical relay

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基金项目

Natural science Foundation of China and Shandong Province(21971149)

Natural science Foundation of China and Shandong Province(92156007)

Natural science Foundation of China and Shandong Province(ZR2019ZD45)

Natural science Foundation of China and Shandong Province(ZR2020KB005)

Fundamental Research Funds of Shandong University()

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量73

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