首页|Phosphine-catalyzed acyl-transfer of heteroaryl ketones for the construction of N-fused heterocycles

Phosphine-catalyzed acyl-transfer of heteroaryl ketones for the construction of N-fused heterocycles

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An inexpensive phosphine catalyst was used effectively for a transition-metal-free acyl-transfer of N-containing heteroaryl ketones for the rapid synthesis of N-fused heterocycles.The key pre-aromatic spiro-cyclic intermediate initialized by the single electron transfer(SET)process of Togni's reagent Ⅱ promoted by the tertiary phosphine resulted in an intriguing and alternative tactic for the cleavage of C-C bonds.By using inexpensive tertiary phosphine as the catalyst,this skeleton-reorganizing approach of N-containing heteroaryl ketones allows a streamlined assembly of complex N-fused heterocycles with broad functional group tolerance.

Phosphine catalysisAcyl-transferN-Fused heterocyclesC-C bond activationAromatization

Yu Zhang、De-Rui Han、Dan Ye、Hong Lu、Hao Wei

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Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education,College of Chemistry & Materials Science,Northwest University,Xi'an 710069,China

国家自然科学基金国家自然科学基金Natural Science Basic Research Program of Shaanxi ProvinceNatural Science Basic Research Plan for Distinguished Young Scholars in Shaanxi Province of ChinaKey Research and Invention Program in Shaanxi Province of China

21971205222712312023-JC-YB-1262022JC-082021SF-299

2024

10.1016/j.cclet.2023.108529

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(3)
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