Abstract
An inexpensive phosphine catalyst was used effectively for a transition-metal-free acyl-transfer of N-containing heteroaryl ketones for the rapid synthesis of N-fused heterocycles.The key pre-aromatic spiro-cyclic intermediate initialized by the single electron transfer(SET)process of Togni's reagent Ⅱ promoted by the tertiary phosphine resulted in an intriguing and alternative tactic for the cleavage of C-C bonds.By using inexpensive tertiary phosphine as the catalyst,this skeleton-reorganizing approach of N-containing heteroaryl ketones allows a streamlined assembly of complex N-fused heterocycles with broad functional group tolerance.
基金项目
国家自然科学基金(21971205)
国家自然科学基金(22271231)
Natural Science Basic Research Program of Shaanxi Province(2023-JC-YB-126)
Natural Science Basic Research Plan for Distinguished Young Scholars in Shaanxi Province of China(2022JC-08)
Key Research and Invention Program in Shaanxi Province of China(2021SF-299)
NETL
NSTL
万方数据