首页|A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy

A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy

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Oral squamous cell carcinoma(OSCC)is known as one of the most malignant tumors with high recur-rence and fatality rate.The poor tumor-targeting ability of traditional chemotherapeutic drugs has been a grand challenge for anti-OSCC therapy.Beyond that,a large quantity of tumor associated macrophages in OSCC tissues further diminish the anti-tumor effects of these drugs.Therefore,we produced a therapeu-tic nano drug delivery system(FA-PEG-PLA-JQ1)through encapsulating JQ1[a small-molecule inhibitor of bromodomain containing protein 4(BRD4)]into the folic acid(FA)-modified nanoparticle(PEG-PLA),which could prolong the half-life of JQ1 and target the tumor tissues.And then,JQ1 released from this nanoparticle could prevent OSCC growth inducing tumor cell apoptosis,inhibiting tumor angiogenesis and the polarization of M2 type macrophages.In conclusion,our date demonstrated the therapeutic ben-efits of FA-PEG-PLA-JQ1 against OSCC in vivo or in vitro,which could be a novel treatment strategy for OSCC in coming days.

Folic acidNanoparticlesJQ1Oral squamous cell carcinomaMacrophages

Dequan Zeng、Zhongkai Ma、Xin Zan、Ting Luo、Xiang Wang、Xiang Gao、Xianghui Fu

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School of Health Management,Xihua University,Chengdu 610039,China

State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China College of Stomatology,Sichuan University,Chengdu 610041,China

Department of Neurosurgery and Institute of Neurosurgery,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,West China Medical School,Sichuan University and Collaborative Innovation Center for Biotherapy,Chengdu 610041,China

Breast Disease Center,Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,China

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国家自然科学基金国家自然科学基金Key Research and Development Projects of the Science and Technology Department of Sichuan Province1-3-5 Project for Disciplines of Excellence,West China Hospital,Sichuan University1-3-5 Project for Disciplines of Excellence,West China Hospital,Sichuan University

32222046821726302021YFS0235ZYJC210222019HXFH017

2024

10.1016/j.cclet.2023.108433

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(3)
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