Abstract
Oral squamous cell carcinoma(OSCC)is known as one of the most malignant tumors with high recur-rence and fatality rate.The poor tumor-targeting ability of traditional chemotherapeutic drugs has been a grand challenge for anti-OSCC therapy.Beyond that,a large quantity of tumor associated macrophages in OSCC tissues further diminish the anti-tumor effects of these drugs.Therefore,we produced a therapeu-tic nano drug delivery system(FA-PEG-PLA-JQ1)through encapsulating JQ1[a small-molecule inhibitor of bromodomain containing protein 4(BRD4)]into the folic acid(FA)-modified nanoparticle(PEG-PLA),which could prolong the half-life of JQ1 and target the tumor tissues.And then,JQ1 released from this nanoparticle could prevent OSCC growth inducing tumor cell apoptosis,inhibiting tumor angiogenesis and the polarization of M2 type macrophages.In conclusion,our date demonstrated the therapeutic ben-efits of FA-PEG-PLA-JQ1 against OSCC in vivo or in vitro,which could be a novel treatment strategy for OSCC in coming days.
基金项目
国家自然科学基金(32222046)
国家自然科学基金(82172630)
Key Research and Development Projects of the Science and Technology Department of Sichuan Province(2021YFS0235)
1-3-5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21022)
1-3-5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(2019HXFH017)
NETL
NSTL
万方数据