首页|Cocktail nano-adjuvant enhanced cancer immunotherapy based on NIR-Ⅱ-triggered in-situ tumor vaccination

Cocktail nano-adjuvant enhanced cancer immunotherapy based on NIR-Ⅱ-triggered in-situ tumor vaccination

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Second near-infrared(NIR-Ⅱ)light triggered in-situ tumor vaccination(ISTV)represents one of the most promising strategies in boosting the whole-body antitumor immunity.While most of previously devel-oped nano-adjuvants for NIR-Ⅱ-triggered ISTV are"all-in-one"formulations,which may indiscriminately damage both the tumor cells and the immune cells,limiting the overall effect of immune response.To overcome this obstacle,we designed a"cocktail"nano-adjuvant by physically mixing hyaluronidases(HAase)-decorated gold nanostars(HA)for NIR-Ⅱ light triggered in situ production of tumor-associated antigens and CpG functionalized gold nanospheres(CA)for immune cells activation.Compared to"all-in-one"formulation,the"cocktail"nano-adjuvants displayed a significantly stronger immune response on NIR-Ⅱ light induced dendritic cells(DCs)mutation and T cells differentiation,greater effect on tumor-growth inhibition,and higher efficacy in inhibition of pulmonary metastases.What is more,increasing the molar ratio of HA to CA led to an enhanced anticancer immune responses.This study highlight the nano-adjuvant formulation effects on the treatment of tumors with multiple targets.

Nano-adjuvantCocktail formulationIn-situ tumor vaccinationNIR-Ⅱ photothermal effectAnticancer immune response

Lilin Fan、Yanwen Feng、Jiang Bian、Anhong Chen、Donglin Xie、Zheng Cao、Jun Yue

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Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials,School of Materials Science and Engineering,Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering,Changzhou University,Changzhou 213164,China

School of Biomedical Engineering,Shenzhen Campus of Sun Yat-sen University,Shenzhen 518107,China

国家自然科学基金Science Technology and Innovation Commission of Shenzhen MunicipalityOpen Research Fund of Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials

52273163JCYJ20190807163003704PML2201

2024

10.1016/j.cclet.2023.108443

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(3)
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