Abstract
Combining phototherapy and chemotherapy has been considered a promising modality for cancer ther-apy due to their synergistic effect.Herein,we developed three D-π-A-structured boron dipyrromethenes(BODIPYs)(named as B-B,B-C,and B-C-Pt).Due to their enlarged π-conjugated structure and high intramolecular charge transfer effect,the synthesized BODIPYs had photothermal conversion capability,and their absorption and fluorescence spectra were red-shifted.The cisplatin-appended BODIPY(B-C-Pt)exhibited good singlet oxygen(1O2)generation ability and near infrared(NIR)absorption and fluores-cence(λAbs=748 nm,λEm=947 nm).After being encapsulated by distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),which could inhibit the H-aggregation of B-C-Pt,the absorp-tion and fluorescence of the obtained B-C-Pt nanoparticles(NPs)were red-shifted to 762 and 985 nm,respectively.The 1O2 quantum yield and photothermal conversion efficiency of the B-C-Pt NPs were 4.0％and 40.6％,respectively.Moreover,B-C-Pt NPs had chemotherapeutic efficacy due to the presence of cis-platin.In vitro and in vivo studies further demonstrated that B-C-Pt NPs had synergistic therapeutic ef-ficacy.Together,B-C-Pt NPs could be employed in NIR Ⅱ fluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy for cancer treatment.
基金项目
国家自然科学基金(62175262)
Science and Technology Innovation Program of Hunan Province(2022RC1201)
中央高校基本科研业务费专项中南大学项目(2019zzts849)
NETL
NSTL
万方数据