首页|Synthesis of photostable near-infrared sulfone-rhodamines for photoacoustic imaging-guided photothermal therapy

Synthesis of photostable near-infrared sulfone-rhodamines for photoacoustic imaging-guided photothermal therapy

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Photothermal therapy(PTT)is a cutting-edge cancer treatment that can kill cancer cells in hypoxic en-vironments without relying on oxygen.Seeking of the ideal photothermal agents with a high absorption coefficient in the near-infrared region,and a high excellent photothermal conversion efficiency is of great significance.Sulfone-Rhodanmine dye has showed an impressive absorption wavelength over 700 nm,but suffered from a stability issue.In this study,we synthesized five sulfone rhodamines and investigated the substitution effects on stability.S02R2 showed high stability and strong absorbance at 714 nm with an excellent photothermal conversion efficiency of 53.06％,making it suitable for accurate photoacoustic imaging-guided photothermal therapy in vivo.

Photothermal therapySulfone rhodamineNear-InfraredPhotoacousticImaging

Huiyu Si、Dongjuan Wang、Xianfa Du、Xin Zhou

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Department of Chemistry,College of Chemistry and Chemical Engineering,Qingdao University,Qingdao 266071,China

Department of Orthopedics,the Affiliated Hospital of Qingdao University,Qingdao 266071,China

国家自然科学基金国家自然科学基金山东省自然科学基金中国博士后科学基金Taishan Scholar Project

2176204521911540466ZR2019YQ12219M652306tsqn201812049

2024

10.1016/j.cclet.2023.108595

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(3)
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