首页|Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF
Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF
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Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable poten-tial for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and superficial.Here we present the chemical characterization of acatulides A-G(1-7)as architecturally un-precedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated fungus.The acatulide structures were elucidated by spectroscopic analysis,modified Mosher's method and single-crystal X-ray diffraction.The plausible biosynthetic pathways for compounds 1-4 are pro-posed.Interestingly,acatulides B-D(2-4)and G(7)were demonstrated to be neuroprotective against the 1-methyl-4-phenylpyridinium(MPP+)-induced damage to SH-SY5Y cells and nematode Caenorhabdi-tis elegans(C.elegans).
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