首页|De novo design of highly efficient type-Ⅰ photosensitizer based onπ-conjugated oligomer for photodynamic eradication of multidrug-resistant bacterial infections

De novo design of highly efficient type-Ⅰ photosensitizer based onπ-conjugated oligomer for photodynamic eradication of multidrug-resistant bacterial infections

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Traditional photosensitizers show limited singlet oxygen generation in hypoxic infection lesions,which greatly suppress their performance in antibacterial therapy.Meanwhile,there still is lack of feasible de-sign strategy for developing hypoxia-overcoming photosensitizers agents.Herein,radical generation of 7r-conjugated small molecules is efficiently manipulated by an individual selenium(Se)substituent.With this strategy,the first proof-of-concept study of a Se-anchored oligo(thienyl ethynylene)(OT-Se)with high-performance superoxide radical(O2·-)and hydroxyl radical('OH)generation capability is present,and achieves efficient antibacterial activities towards the clinically extracted multidrug-resistant bacteria methicillin-resistant S.aureus(MRSA)and carbapenem-resistant E.coli(CREC)at sub-micromolar con-centration under a low white light irradiation(30 mW/cm2).The water-dispersible OT-Se shows a good bacteria-anchoring capability,biocompatibility,and complete elimination of multidrug-resistant bacteria wound infection in vivo.This work offers a strategy to boost type-Ⅰ photodynamic therapy(PDT)perfor-mance for efficient antibacterial treatments,advancing the development of antibacterial agents.

Photodynamic therapyAntibacterialType-Ⅰ photosensitizersMultidrug-resistant bacteriaConjugated oligomers

Qi Zhao、Guangchao Qing、Jie Yu、Ying Liu、Jianliang Shen、Yang Luo、Xingjie Zan、Shengliang Li

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State Key Laboratory of Ophthalmology,Optometry and Vision Science,School of Ophthalmology and Optometry,School of Biomedical Engineering,Wenzhou Medical University

Wenzhou Institute,University of Chinese Academy of Sciences

Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou 325001,China

College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China

Center of Smart Laboratory and Molecular Medicine,School of Medicine,Chongqing University,Chongqing 400044,China

College of Life Science and Laboratory Medicine,Kunming Medical University,Kunming 650050,China

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国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金浙江省自然科学基金Wenzhou Medical UniversityUniversity of Chinese Academy of ScienceUniversity of Chinese Academy of Science

821250228207238331800833219770815217313522207024LZ19H180001KYYW201901WIBEZD2017001-03WIUCASYJ2020001

2024

10.1016/j.cclet.2023.108535

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(3)
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