Abstract
The application of photothermal therapy(PTT)is greatly limited by the low accumulation of photother-mal agents,uneven photothermal distribution,and heat endurance of cancer cells.Worse still,despite PTT enhances immunogenicity,the anti-tumor immune efficacy is still unsatisfactory due to the ineffi-cient immunogenic cell death(ICD)induction and poor infiltration of immune cells.To solve the above problems of PTT,we developed hyaluronic acid(HA)modified hollow copper sulfide nanoparticles en-capsulating diethyldithiocarbamate(DDTC)to construct a breast tumor targeting and near infrared(NIR)photo-responsive drug delivery system(D-HCuS@HA),which further combined with losartan to improve the accumulation and penetration in the tumor site.Upon irradiation,D-HCuS@HA realized enhanced PTT and released cytotoxic Cu(DDTC)2 to eliminate heat endurance tumor cells,thereby enhancing anti-tumor effect and inducing effective ICD.Moreover,the combination with losartan could remodel the tu-mor microenvironment,allowing more T cells to infiltrate into the tumor,and significantly inhibiting the occurrence and development of metastatic tumors.In vitro/vivo results revealed the great potential of D-HCuS@HA combined with losartan,which provides a new paradigm for anti-tumor and anti-metastases.
基金项目
国家自然科学基金(82173762)
Research Funds of Sichuan Science and Technology Department(2022JDJQ0050)
Research Funds of Sichuan Science and Technology Department(2022YFS0334)
高等学校学科创新引智计划(111计划)(B18035)
NETL
NSTL
万方数据