首页|Combination losartan with hyaluronic acid modified diethyldithiocarbamate loaded hollow copper sulfide nanoparticles for the treatment of breast cancer and metastasis

Combination losartan with hyaluronic acid modified diethyldithiocarbamate loaded hollow copper sulfide nanoparticles for the treatment of breast cancer and metastasis

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The application of photothermal therapy(PTT)is greatly limited by the low accumulation of photother-mal agents,uneven photothermal distribution,and heat endurance of cancer cells.Worse still,despite PTT enhances immunogenicity,the anti-tumor immune efficacy is still unsatisfactory due to the ineffi-cient immunogenic cell death(ICD)induction and poor infiltration of immune cells.To solve the above problems of PTT,we developed hyaluronic acid(HA)modified hollow copper sulfide nanoparticles en-capsulating diethyldithiocarbamate(DDTC)to construct a breast tumor targeting and near infrared(NIR)photo-responsive drug delivery system(D-HCuS@HA),which further combined with losartan to improve the accumulation and penetration in the tumor site.Upon irradiation,D-HCuS@HA realized enhanced PTT and released cytotoxic Cu(DDTC)2 to eliminate heat endurance tumor cells,thereby enhancing anti-tumor effect and inducing effective ICD.Moreover,the combination with losartan could remodel the tu-mor microenvironment,allowing more T cells to infiltrate into the tumor,and significantly inhibiting the occurrence and development of metastatic tumors.In vitro/vivo results revealed the great potential of D-HCuS@HA combined with losartan,which provides a new paradigm for anti-tumor and anti-metastases.

Targeted drug delivery systemHollow copper sulfide nanoparticlesPhotothermal therapyHyaluronic acidBreast cancerAnti-metastasis

Haili Hu、Weiwei Zhang、Lei Lei、Fan Tong、Huilin Zhang、Yiwei Zhang、Wenqin Yang、Yilu Tang、Ruyi Lin、Xue Xia、Jiamei Li、Shiyong Song、Huile Gao

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Key Laboratory of Drug Targeting and Drug Delivery Systems,West China School of Pharmacy,Sichuan University,Chengdu 610041,China

Department of Public Health,Chengdu Medical College,Chengdu 610500,China

School of Pharmacy,Henan University,Kaifeng 475004,China

国家自然科学基金Research Funds of Sichuan Science and Technology DepartmentResearch Funds of Sichuan Science and Technology Department高等学校学科创新引智计划(111计划)

821737622022JDJQ00502022YFS0334B18035

2024

10.1016/j.cclet.2023.108765

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(3)
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