首页|Simple-structured hydrophilic sensors for sweat uric acid detection with laser-engraved polyimide electrodes and cellulose paper substrates

Simple-structured hydrophilic sensors for sweat uric acid detection with laser-engraved polyimide electrodes and cellulose paper substrates

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Accurate detection of uric acid(UA)is crucial for diagnosing gout,yet traditional sweat-based UA sen-sors continue to face challenges posed by complex and costly electrode fabrication methods,as well as weakly hydrophilic substrates.Here,we designed and developed simple,low-cost,and hydrophilic sweat UA detection sensors constructed by carbon electrodes and cellulose paper substrates.The carbon elec-trodes were made by carbonized polyimide films through a simple,one-step laser engraving method.Our electrodes are porous,possess a large specific surface area,and are flexible and conductive.The sub-strates were composed of highly hydrophilic cellulose paper that can effectively collect,store,and trans-port sweat.The constructed electrodes demonstrate high sensitivity of 0.4 μA L μmol-1 cm-2,wide linear range of 2-100 μmol/L.In addition,our electrodes demonstrate high selectivity,excellent reproducibil-ity,high flexibility,and outstanding stability against mechanical bending,temperature variations,and extended storage periods.Furthermore,our sensors have been proven to provide reliable results when detecting UA levels in real sweat and on real human skin.We envision that these sensors hold enormous potential for use in the prognosis,diagnosis,and treatment of gout.

Laser-engraved carbonPolyimideCellulose paperHydrophilicitySweat uric acid

Linhe Xu、Xueshan Hu、Shuang Zhou、Ze Zhang、Junxian Zhang、Chao Li、Daxian Zuo、Hao Liu、Gang Chen、Jiayu Wan、Jinsong Tao

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State Key Lab of Pulp and Paper Engineering,South China University of Technology,Guangzhou 510640,China

Future Battery Research Center,Global Institute of Future Technology,Shanghai Jiao Tong University,Shanghai 200240,China

Guangdong Basic and Applied Basic Research FoundationGuangzhou City Industrial Science and Technology Projectsfund from Guangxi China Tobacco Industry Co.,Ltdfund for the construction of Bengbu-SCUT Research Center for Advanced Manufacturing of Biomaterials国家重点研发计划

2023A15150113882022010100592022450000340057202101902018YFC1902102

2024

10.1016/j.cclet.2023.109103

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(3)
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