Abstract
Accurate detection of uric acid(UA)is crucial for diagnosing gout,yet traditional sweat-based UA sen-sors continue to face challenges posed by complex and costly electrode fabrication methods,as well as weakly hydrophilic substrates.Here,we designed and developed simple,low-cost,and hydrophilic sweat UA detection sensors constructed by carbon electrodes and cellulose paper substrates.The carbon elec-trodes were made by carbonized polyimide films through a simple,one-step laser engraving method.Our electrodes are porous,possess a large specific surface area,and are flexible and conductive.The sub-strates were composed of highly hydrophilic cellulose paper that can effectively collect,store,and trans-port sweat.The constructed electrodes demonstrate high sensitivity of 0.4 μA L μmol-1 cm-2,wide linear range of 2-100 μmol/L.In addition,our electrodes demonstrate high selectivity,excellent reproducibil-ity,high flexibility,and outstanding stability against mechanical bending,temperature variations,and extended storage periods.Furthermore,our sensors have been proven to provide reliable results when detecting UA levels in real sweat and on real human skin.We envision that these sensors hold enormous potential for use in the prognosis,diagnosis,and treatment of gout.
基金项目
Guangdong Basic and Applied Basic Research Foundation(2023A1515011388)
Guangzhou City Industrial Science and Technology Projects(202201010059)
fund from Guangxi China Tobacco Industry Co.,Ltd(2022450000340057)
fund for the construction of Bengbu-SCUT Research Center for Advanced Manufacturing of Biomaterials(20210190)
国家重点研发计划(2018YFC1902102)
NETL
NSTL
万方数据