Abstract
Nanomaterials with enzyme-mimic(nanozyme)activity have garnered considerable attention as a poten-tial alternative to natural enzymes,thanks to their low preparation cost,high activity,ease of preser-vation,and unique physicochemical properties.Vanadium(Ⅴ)is a transition metal that integrates the benefits of valence-richness,low cost,and non-toxicity,making it a desirable candidate for develop-ing a range of emerging nanozymes.In this review,we provide the first systematic summary of recent research progress on Ⅴ-based nanozymes.First,we summarize the preparation of Ⅴ-based nanozymes using both top-down and bottom-up synthesis methods.Next,we review the mechanism of Ⅴ-based nanozymes that mimic the activity of various enzymes.We then discuss methods for regulating Ⅴ-based nanozyme activity,including morphology,size,valence engineering,defect engineering,external trigger-ing,and surface engineering.Afterward,we outline various biomedical applications,including therapeu-tic,anti-inflammatory,antibacterial,and biosensing.Finally,we prospect the challenges and countermea-sures for Ⅴ-based nanozymes based on their development.By summarizing recent research progress onⅤ-based nanozymes,we hope to provide useful insights for researchers to further explore their potential applications and overcome their existing challenges.
基金项目
"Double First-Class"University project(CPU2018GY25)
Jiangsu Innovation and Enterpreneurship()
NETL
NSTL
万方数据