首页|Probing the dynamic thermodynamic resolution and biological activity of Cu(Ⅱ)and Pd(Ⅱ)complexes with Schiff base ligand derived from proline

Probing the dynamic thermodynamic resolution and biological activity of Cu(Ⅱ)and Pd(Ⅱ)complexes with Schiff base ligand derived from proline

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Schiff base metal complexes are of great importance in pharmaceutical science owing to their unique chemical properties,which enable them to exhibit diverse biological activities such as anti-bacterial,anti-oxidant,anti-inflammatory,and anti-tumor properties.Furthermore,Schiff base metal complexes can serve as reagents and catalysts in chemical reactions.This review aims to provide an overview of our re-cently published studies on Cu(Ⅱ)and Pd(Ⅱ)complexes derived from proline Schiff base ligands.We also discuss the potential applications of these metal complexes in the fields of antibacterial and chiral reso-lution.

Schiff basesBiological activityTailor-made amino acidsAsymmetric synthesisChiral tridentate ligandsSquare-planar Cu(Ⅱ)-complexesSquare-planar Pd(Ⅱ)-complexes

Tao Yu、Vadim A.Soloshonok、Zhekai Xiao、Hong Liu、Jiang Wang

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State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

School of Pharmacy,University of Chinese Academy of Sciences,Beijing 100049,China

Department of Organic Chemistry I,Faculty of Chemistry,University of the Basque Country UPV/EHU,San Sebastian 20018,Spain

IKERBASQUE,Basque Foundation for Science,Bilbao 48013,Spain

School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,UCAS,Hangzhou 310024,China

Lingang Laboratory,Shanghai 200031,China

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国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金Lingang LaboratoryLingang Laboratory

2022YFA130290082130105922533058212100522177124LG-GG-202204-02LG202103-04-01

2024

10.1016/j.cclet.2023.108901

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(4)
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