首页|Recent advances in electrocatalytic generation of indole-derived radical cations and their applications in organic synthesis

Recent advances in electrocatalytic generation of indole-derived radical cations and their applications in organic synthesis

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Indole-derived radical cations,open-shell reactive species,display distinctive dual reactivity due to the carbon-centered radical and more electrophilic carbocation,which frequently appear in a variety of sin-gle electron oxidation reactions for synthesizing structurally diverse functionalized indoles and indo-lines.Electrocatalysis is considered as a synthetically attractive and environmentally friendly alternative for driving the single electron oxidation of indoles.Remarkable achievements in electrocatalytic indole-derived radical cation-mediated indole functionalization have been realized so far.This review compre-hensively summarizes the recent progresses in the applications of electrocatalytic indole radical cations,including C(sp2)-H functionalization,dearomative 2,3-difunctionalization,and ring-opening reaction,em-phasizing the vital single electron oxidation steps of indoles,the substrates scope and limitations,and the reaction mechanisms.

ElectrocatalysisIndole radical cationC-H functionalizatinDearomative 2,3-difunctionalization

Wei Zhou、Xi Chen、Lin Lu、Xian-Rong Song、Mu-Jia Luo、Qiang Xiao

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Key Laboratory of Organic Chemistry of Jiangxi Province,Jiangxi Science & Technology Normal University,Nanchang 330013,China

国家自然科学基金江西省自然科学基金江西省教育厅项目江西省教育厅项目Ph.D.start up fund of Jiangxi Science and Technology Normal University

2226101920224BAB213004GJJ211134GJJ2111372021BSQD32

2024

10.1016/j.cclet.2023.108902

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(4)
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