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mide naphthotubes:Biomimetic macrocycles for selective molecular recognition

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Selective molecular recognition in water is routine for bioreceptors,but remains challenging for synthetic hosts.This is principally because noncovalent interactions are usually less efficient in aqueous environ-ments.By mimicking the cavity feature of bioreceptors,Prof.Wei Jiang proposed and clarified the concept of"endo-functionalized cavity".Through situating polar binding sites into a deep hydrophobic cavity,we designed and synthesized several macrocyclic hosts,among which amide naphthotubes are the most rep-resentative.The hosts can selectively recognize various polar molecules including organic micropollutants,drug molecules,and chiral molecules in water by employing the hydrophobic effect and shielded hydro-gen bonding.In addition,these biomimetic hosts have been applied in spectroscopic analysis,adsorptive separation and self-assembly.In this review,we provide an overview of recent advances on amide naph-thotubes with special emphasis on the efforts of Jiang's group.We are convinced that these biomimetic macrocycles will make further contributions to supramolecular chemistry and beyond.

Molecular recognitionSupramolecular chemistryAmide naphthotubeEndo-functionalized cavityBiomimetic macrocycle

Cheng-Da Zhao、Huan Yao、Shi-Yao Li、Fangfang Du、Li-Li Wang、Liu-Pan Yang

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School of Pharmaceutical Science,Postdoctoral Research Station of Basic Medicine,Hengyang Medical School,University of South China,Hengyang 421001,China

国家自然科学基金国家自然科学基金湖南省自然科学基金湖南省自然科学基金Young Science and Tech-nology Innovation Program of Hunan Province中国博士后科学基金

22174059222011282022JJ403632022JJ403652022RC12302022M721542

2024

10.1016/j.cclet.2023.108879

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(4)
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