Abstract
Selective molecular recognition in water is routine for bioreceptors,but remains challenging for synthetic hosts.This is principally because noncovalent interactions are usually less efficient in aqueous environ-ments.By mimicking the cavity feature of bioreceptors,Prof.Wei Jiang proposed and clarified the concept of"endo-functionalized cavity".Through situating polar binding sites into a deep hydrophobic cavity,we designed and synthesized several macrocyclic hosts,among which amide naphthotubes are the most rep-resentative.The hosts can selectively recognize various polar molecules including organic micropollutants,drug molecules,and chiral molecules in water by employing the hydrophobic effect and shielded hydro-gen bonding.In addition,these biomimetic hosts have been applied in spectroscopic analysis,adsorptive separation and self-assembly.In this review,we provide an overview of recent advances on amide naph-thotubes with special emphasis on the efforts of Jiang's group.We are convinced that these biomimetic macrocycles will make further contributions to supramolecular chemistry and beyond.
基金项目
国家自然科学基金(22174059)
国家自然科学基金(22201128)
湖南省自然科学基金(2022JJ40363)
湖南省自然科学基金(2022JJ40365)
Young Science and Tech-nology Innovation Program of Hunan Province(2022RC1230)
中国博士后科学基金(2022M721542)
NETL
NSTL
万方数据