Scalable production of mesoporous titanium nanoparticles through sequential flash nanocomplexation

Feng Cui ¹Fangman Chen ¹Xiaochun Xie ²Chenyang Guo ¹Kai Xiao ²Ziping Wu ³Yinglu Chen ³Junna Lu ¹Feixia Ruan ²Chuanxu Cheng ¹Chao Yang ⁴Dan Shao⁵

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作者信息

1. School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou International Campus,Guangzhou 511442,China;National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou 510006,China
2. Institutes for Life Sciences,School of Medicine,South China University of Technology,Guangzhou 510006,China;National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou 510006,China
3. School of Biology and Biological Engineering,South China University of Technology,Guangzhou 510006,China;National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou 510006,China
4. School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou International Campus,Guangzhou 511442,China;Department of Orthopedics,Academy of Orthopedics-Guangdong Province,Orthopedic Hospital of Guangdong Province,Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases,The Third Affiliated Hospital of Southern Medical University,Guangzhou 510665,China
5. School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou International Campus,Guangzhou 511442,China;Institutes for Life Sciences,School of Medicine,South China University of Technology,Guangzhou 510006,China;National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou 510006,China
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Abstract

Mesoporous titanium nanoparticles(MTNs)have emerged as an important porous semiconductor owning to their large surface area and unique electronic/optical properties.However,the fundamental research for rational manufacturing MTNs in a highly scalable manner remains a challenge.In this study,we report a two-step flash nanocomplexation(FNC)approach to large-scalable generate MTNs through the sequen-tial combination of two multi-inlet vortex mixers.By optimizing the concentrated titanium precursor,polyethylene glycol(PEG)-functionalized silane amount and pH,we have been able to produce MTNs with small particle size(31.5 nm),larger surface area(416.9 m2/g)and pore volume(0.59 cm3/g).Different from the traditional MTNs bulk,FNC-produced MTNs exhibited well-controlled manner and exceptional photo-catalytic and antibacterial properties.Importantly,the optimized MTNs outperformed commercial P25 not only in protecting ultraviolet A(UVA)-exposed skin,but also in treating P.aeruginosa-infected wound.We believe that the high controllability and scalability of sequential flash nanocomplexation method offers great opportunities in enhancing the performance of mesoporous titanium nanoparticles.

Key words

Mesoporous titanium nanoparticles/Flash nanocomplexation/Photocatalytic/Antibacterial/Sequential

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基金项目

国家自然科学基金(32271388)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量48

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