首页|Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy
Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy
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Photoacoustic agents combining photodynamic therapy(PDT)and photothermal therapy(PTT)functions have emerged as potent theranostic agents for combating cancer.The molecular approaches for enhancing the near-infrared(NIR)-absorption and maximizing non-radiative energy transfer are essential for effec-tive photoacoustic imaging(PAI)and therapy applications.In addition,such molecules with high speci-ficity and affinity to cancer cells are urgently needed,which would further decrease the side effect during treatments.In this study,we applied a heavy-atom engineering strategy and introduced p-aminophenol,-thio,and-seleno moieties into NIR heptamethine cyanine(Cy7)skeleton(Cy7-X-NH2,X=O,S,Se)to sig-nificantly increase photothermal conversion efficiency for PTT and promote intersystem crossing for PDT.Additionally,we designed a series of nitroreductase(NTR)-activated photoacoustic probes(Cy7-X-NO2,X=O,S,Se),and target hypoxic tumors with NTR overexpression.Our prostate cancer targeting probe,Cy7-Se-NO2-KUE,exhibited specific tumor photoacoustic signals and effective tumor killing through out-standing synergistic PTT/PDT in vivo.These findings highlighted a versatile strategy for cancer photoa-coustic diagnosis and enhanced phototherapy.
Heavy-atom effectPhototherapyPhotoacoustic imagingHypoxia-responsiveProstate cancer
Department of Urology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China
State Key Laboratory of Bioactive Substances and Function of Natural Medicine,Institute of Materia Medica,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100050,China
国家重点研发计划国家自然科学基金国家自然科学基金Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences
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