Abstract
Photoacoustic agents combining photodynamic therapy(PDT)and photothermal therapy(PTT)functions have emerged as potent theranostic agents for combating cancer.The molecular approaches for enhancing the near-infrared(NIR)-absorption and maximizing non-radiative energy transfer are essential for effec-tive photoacoustic imaging(PAI)and therapy applications.In addition,such molecules with high speci-ficity and affinity to cancer cells are urgently needed,which would further decrease the side effect during treatments.In this study,we applied a heavy-atom engineering strategy and introduced p-aminophenol,-thio,and-seleno moieties into NIR heptamethine cyanine(Cy7)skeleton(Cy7-X-NH2,X=O,S,Se)to sig-nificantly increase photothermal conversion efficiency for PTT and promote intersystem crossing for PDT.Additionally,we designed a series of nitroreductase(NTR)-activated photoacoustic probes(Cy7-X-NO2,X=O,S,Se),and target hypoxic tumors with NTR overexpression.Our prostate cancer targeting probe,Cy7-Se-NO2-KUE,exhibited specific tumor photoacoustic signals and effective tumor killing through out-standing synergistic PTT/PDT in vivo.These findings highlighted a versatile strategy for cancer photoa-coustic diagnosis and enhanced phototherapy.
基金项目
国家重点研发计划(2022YFE0199700)
国家自然科学基金(22077139)
国家自然科学基金(22122705)
Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2022-I2M-2-002)
NETL
NSTL
万方数据