Abstract
A novel D-π-A structure and near-infrared fluorescent probe(DCITT)with high polarity sensitivity and membrane targeting was reported.The fluorescent spectra of DCITT were polarity dependent and Stokes shift was greater than 300 nm.Due to its high fluorescence quantum yield,low cytotoxicity and photosta-bility,DCITT could be used as a labeling probe in multicellular organisms.In particular,DCITT effectively distinguished tumor cells from normal cells because it could specifically light up the cancer cells mem-brane based on strong red fluorescence for a long time.On this basis,a polar-sensitive cell membrane probe is developed to differentiate tumor cells from normal cells,which provides an idea and method for the early diagnosis of tumor at cellular level.
基金项目
Henan Provincial Science and Tech-nology Research Project(232102310369)
NETL
NSTL
万方数据