首页|Water-soluble and polarity-sensitive near-infrared fluorescent probe for long-time specific cancer cell membranes imaging and C.Elegans label
Water-soluble and polarity-sensitive near-infrared fluorescent probe for long-time specific cancer cell membranes imaging and C.Elegans label
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A novel D-π-A structure and near-infrared fluorescent probe(DCITT)with high polarity sensitivity and membrane targeting was reported.The fluorescent spectra of DCITT were polarity dependent and Stokes shift was greater than 300 nm.Due to its high fluorescence quantum yield,low cytotoxicity and photosta-bility,DCITT could be used as a labeling probe in multicellular organisms.In particular,DCITT effectively distinguished tumor cells from normal cells because it could specifically light up the cancer cells mem-brane based on strong red fluorescence for a long time.On this basis,a polar-sensitive cell membrane probe is developed to differentiate tumor cells from normal cells,which provides an idea and method for the early diagnosis of tumor at cellular level.
NIR-fluorescent probePolarity-sensitiveBioimagingTargeting cell membraneDifferentiate tumor and normal cells
Lixian Fu、Yiyun Tan、Yue Ding、Weixia Qing、Yong Wang
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Henan International Joint Laboratory of Medicinal Plants Utilization,College of Chemistry and Molecular Sciences,Henan University,Kaifeng 475004,China
School of Basic Medical Science,Henan University,Kaifeng 475004,China
Henan Provincial Science and Tech-nology Research Project
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