首页|Oxidative cyclization of allyl compounds and isocyanide:A facile entry to polysubstituted 2-cyanopyrroles
Oxidative cyclization of allyl compounds and isocyanide:A facile entry to polysubstituted 2-cyanopyrroles
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A facile TfOH-catalyzed oxidative cyclization of allyl compounds and isocyanide has been developed with the assistance of DDQ,where isocyanide is used as the crucial"N"and"CN"sources.Highly function-alized 2-cyanopyrroles are constructed efficiently through a new formal[3+2]mode,demonstrating di-verse reactivity and synthetic utility in organic chemistry.2-Cyanopyrrole is converted into a nucleobase analogue of Remdesivir and 5H-pyrrolo[2,1-a]isoindole through a three-step or a two-step sequence,re-spectively.This protocol features broad substrate scope,operational simplicity and good functional group tolerance.
Department of Chemistry,Affiliated Nantong Hospital of Shanghai University(The Sixth People's Hospital of Nantong),Shanghai Engineering Research Center of Organ Repair,Innovative Drug Research Center,School of Medicine,Shanghai University,Shanghai 200444,China
State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China
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