Abstract
One of the largest subfamilies within the famous Daphniphyllum alkaloid family is made up of the yuzurimine-type(or macrodaphniphyllamine-type)alkaloids.Their complex aza-polycyclic caged struc-tures,several contiguous stereogenic centers,and vicinal all-carbon quaternary centers make these al-kaloids formidable challenge for synthetic chemists.Recently,synthesis of these alkaloids has received extensive attention from our community.Herein,we wish to report the total synthesis of C14-epi-deoxycalyciphylline H,a putative member of yuzurimine-type alkaloid subfamily.Key transformations employed in our approach include an intramolecular Prins reaction and a Pd-catalyzed enyne cycloiso-merization.In addition,synthesis of a daphnezomine L-type alkaloid,paxdaphnidine A,was also studied.
基金项目
国家自然科学基金(21971104)
国家自然科学基金(22271136)
Shenzhen Key Lab-oratory of Small Molecule Drug Discovery and Synthesis(ZDSYS20190902093215877)
Guangdong Provincial Key Laboratory of Catalysis(2020B121201002)
Guangdong Innovative Pro-gram(2019BT02Y335)
Education Department of Guangdong Province,Key research projects in colleges and universities in Guangdong Province(2021ZDZX2035)
Shenzhen Nobel Prize Scientists Laboratory Project(C17783101)
Innovative Team of Universities in Guangdong Province(2020KCXTD016)
NETL
NSTL
万方数据