Electrochemical construction of 2,5-diaryloxazoles via N-H and C(sp3)-H functionalization

Tong Li ¹Leping Pan ²Yan Zhang ¹Jihu Su ³Kai Li ¹Kuiliang Li ¹Hu Chen ¹Qi Sun ¹Zhiyong Wang¹

扫码查看

作者信息

1. Hefei National Center for Physical Sciences at Microscale,Key Laboratory of Precision and Intelligent Chemistry,School of Chemistry and Materials Science,University of Science and Technology of China,Hefei 230026,China
2. Anhui University of Science and Technology,Huainan 232001,China
3. CAS Key Laboratory of Microscale Magnetic Resonance,Department of Modern Physics,University of Science and Technology of China,Hefei 230026,China
折叠

Abstract

An efficient N-H and C(sp3)-H functionalization of aryl ketones with benzylamines/amino acids was developed under mild conditions by virtue of anodic oxidation.A variety of functionalized 2,5-diaryloxazoles were obtained with good to excellent yields.Moreover,some important natural products can be prepared by this method.The reaction features a broad substrate scope,scalability,metal-free and chemical oxidant-free.

Key words

Electrochemical/Metal-free/Oxazole/Oxidant-free

引用本文复制引用

基金项目

国家自然科学基金(21772185)

国家自然科学基金(22001241)

Science and Technology Major Project of An-hui Province of China(201903a07020003)

Science and Technology Major Project of Fuyang of Anhui Province of China(FK20208018)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量1

段落导航