Efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates:A concise synthesis of difluoromethylene-containing 1,4-thiazine derivatives
Zhiwei Chen 1Heyun Sheng 1Xue Li 1Menghan Chen 1Xin Li 1Qiuling Song2
作者信息
- 1. Institute of Next Generation Matter Transformation,College of Materials Science & Engineering and College of Chemical Engineering at Huaqiao University,Xiamen 361021,China
- 2. Institute of Next Generation Matter Transformation,College of Materials Science & Engineering and College of Chemical Engineering at Huaqiao University,Xiamen 361021,China;Fujian University Key Laboratory of Molecule Synthesis and Function Discovery,College of Chemistry,Fuzhou University,Fuzhou 350108,China;State Key Laboratory of Organometallic Chemistry and Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China
- 折叠
Abstract
A practical method for the construction of difluoromethylene-containing 1,4-thiazine moieties using read-ily available diethyl bromodifluoromethanephosphonate(BrCF2PO(OEt)2)as difluorocarbene precusor has been developed.This transformation features the efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates.A series of structurally novel and functionalized difluoromethylene-containing 1,4-thiazine derivatives were thus synthesized in good yields.
Key words
Difluoromethylene/Pyridinium 1,4-zwitterionic thiolates/1,4-Thiazine derivatives引用本文复制引用
基金项目
国家自然科学基金(21931013)
国家自然科学基金(22271105)
福建省自然科学基金(2022J02009)
Open Research Fund of School of Chemistry and Chemical Engineering,Henan Nor-mal University()
Subsidized Project for Cultivating Postgraduates'Innovative Ability in Scientific Research of Huaqiao University()
出版年
2024
NETL
NSTL
万方数据