首页|Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment

Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment

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Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation.However,it is difficult to accurately reveal liposome deliv-ery modes and drug release rates at different pH values to assess the biodistribution and drug deliv-ery pathways in vivo.Here,we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects,namely lipo/Bi-doped CQDs.Lipo/Bi-doped CQDs show good water solubility and physicochemical properties,which can be used for in vitro labeling of colon cancer(CT26)cells and in vivo imaging localization tracking tumors for mon-itoring.Simultaneously,thanks to the excellent pH sensitivity and ion doping characteristic of Bi-doped CQDs,lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different pH values and exhibit potential effects in vivo antitumor therapy.

Bi-doped CQDsLipo/Bi-doped CQDspH sensitivityIn vitro/in vivo imagingDiagnosis and treatment integration

Peide Zhu、Yangjia Liu、Yaoyao Tang、Siqi Zhu、Xinyang Liu、Lei Yin、Quan Liu、Zhiqiang Yu、Quan Xu、Dixian Luo、Juncheng Wang

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State Key Laboratory of Heavy Oil Processing,China University of Petroleum-Beijing,Beijing 102249,China

Department of Laboratory Medicine,Dongguan Institute of Clinical Cancer Research,Affiliated Dongguan Hospital,Southern Medical University,Dongguan 523058,China

Department of Laboratory Medicine,Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital),Shenzhen 518052,China

Institute of Stomatology,First Medical Center,Chinese PLA General Hospital,Beijing 100853,China

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北京市自然科学基金北京市自然科学基金Military Health Care ProjectScience Foundation of China University of PetroleumScience Foundation of China University of Petroleum国家自然科学基金国家自然科学基金Guang-dong Provincial Basic and Applied Basic Research FoundationGuang-dong Provincial Basic and Applied Basic Research FoundationScience and Technology In-novation Commission of ShenzhenScience and Technology In-novation Commission of ShenzhenScience and Technology Plan of Shen-zhen Nanshan DistrictDiscipline Leader Foundation of Huazhong University of Science and Technology Union Shenzhen HospitalCrosswise Project of Daan Gene

L222109322201822BJZ222462019QNXZ022462019BJRC00752211530034822732362022A1515220042022A1515220042JSGG20210802153410031JCYJ20220530141609021NS016YN2021002HXKY2022002

2024

10.1016/j.cclet.2023.108689

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(4)
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