中国化学快报(英文版)2024，Vol.35Issue(4) ：414-419.DOI:10.1016/j.cclet.2023.108689

Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment

Peide Zhu Yangjia Liu Yaoyao Tang Siqi Zhu Xinyang Liu Lei Yin Quan Liu Zhiqiang Yu Quan Xu Dixian Luo Juncheng Wang
中国化学快报(英文版)2024，Vol.35Issue(4) ：414-419.DOI:10.1016/j.cclet.2023.108689
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Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment

Peide Zhu 1Yangjia Liu 2Yaoyao Tang 1Siqi Zhu 3Xinyang Liu 1Lei Yin 3Quan Liu 3Zhiqiang Yu 2Quan Xu 1Dixian Luo 3Juncheng Wang4
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作者信息

  • 1. State Key Laboratory of Heavy Oil Processing,China University of Petroleum-Beijing,Beijing 102249,China
  • 2. Department of Laboratory Medicine,Dongguan Institute of Clinical Cancer Research,Affiliated Dongguan Hospital,Southern Medical University,Dongguan 523058,China
  • 3. Department of Laboratory Medicine,Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital),Shenzhen 518052,China
  • 4. Institute of Stomatology,First Medical Center,Chinese PLA General Hospital,Beijing 100853,China
  • 折叠

Abstract

Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation.However,it is difficult to accurately reveal liposome deliv-ery modes and drug release rates at different pH values to assess the biodistribution and drug deliv-ery pathways in vivo.Here,we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects,namely lipo/Bi-doped CQDs.Lipo/Bi-doped CQDs show good water solubility and physicochemical properties,which can be used for in vitro labeling of colon cancer(CT26)cells and in vivo imaging localization tracking tumors for mon-itoring.Simultaneously,thanks to the excellent pH sensitivity and ion doping characteristic of Bi-doped CQDs,lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different pH values and exhibit potential effects in vivo antitumor therapy.

Key words

Bi-doped CQDs/Lipo/Bi-doped CQDs/pH sensitivity/In vitro/in vivo imaging/Diagnosis and treatment integration

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基金项目

北京市自然科学基金(L222109)

北京市自然科学基金(3222018)

Military Health Care Project(22BJZ22)

Science Foundation of China University of Petroleum(2462019QNXZ02)

Science Foundation of China University of Petroleum(2462019BJRC007)

国家自然科学基金(52211530034)

国家自然科学基金(82273236)

Guang-dong Provincial Basic and Applied Basic Research Foundation(2022A151522004)

Guang-dong Provincial Basic and Applied Basic Research Foundation(2022A1515220042)

Science and Technology In-novation Commission of Shenzhen(JSGG20210802153410031)

Science and Technology In-novation Commission of Shenzhen(JCYJ20220530141609021)

Science and Technology Plan of Shen-zhen Nanshan District(NS016)

Discipline Leader Foundation of Huazhong University of Science and Technology Union Shenzhen Hospital(YN2021002)

Crosswise Project of Daan Gene(HXKY2022002)

出版年

2024
中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCDCSCD
影响因子：0.771
ISSN：1001-8417
参考文献量1
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