Abstract
Chiral alcohols and amines are important structural units widely existing in pharmaceuticals,agrochem-icals,and food additives.Dynamic kinetic resolution(DKR)is an efficient strategy to deliver optically active alcohols and amines from their racemates.For the development of DKR method,racemization cat-alyst plays as a crucial element with the requirement of compatibility with the kinetic resolution(KR)system.In this paper,recent advance in the catalytic racemization of secondary alcohols and amines is summarized based on different types of racemizing intermediates,which are redox racemization via ketone/imine intermediates,racemization via radical intermediates,and racemization via carbocation in-termediates.Enzymatic racemization of secondary alcohols and amines is also enclosed.
基金项目
国家自然科学基金(22271054)
the"1000-Youth Talents Plan"()
Fudan University(startup grant)()
维普
万方数据