首页|Metal-organic framework and its composites modulate macrophage polarization in the treatment of inflammatory diseases

Metal-organic framework and its composites modulate macrophage polarization in the treatment of inflammatory diseases

扫码查看
原文链接
  • 万方数据
  • 维普
Metal-organic framework(MOF)is a periodic sexual network structure with large surface area and high porosity,which is assembled by inorganic nodes and organic ligands through coordinate covalent bond.MOFs have the advantages of controllable pore size and shape,large specific surface area,easy modi-fication and more active sites.In addition,MOF based nanoenzymes display excellent enzyme catalytic activity due to their special structure and multiple exposed metal active sites,controlling the production of reactive oxygen species(ROS)in cells or the body,and thus regulating the polarization of macrophage.This article reviews the mechanism of MOF material regulating macrophage polarization and the function of macrophages with different phenotypes.By utilizing the excellent properties of MOFs and the advan-tages of combining them with bioactive materials,we have discovered their excellent applications in the treatment of inflammatory diseases.Finally,we discussed the current challenges and prospects faced by MOF based composite materials.We expect that the research in this developing field will play a more important role in combating inflammatory diseases in the field of nanomedicine.

Metal-organic frameworkInflammationMacrophage polarizationReactive oxygen speciesNanozyme activity

Feifei Wang、Hang Yao、Xinyue Wu、Yijian Tang、Yang Bai、Hui Chong、Huan Pang

展开 >

School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou 225002,China

School of Pharmacy,Changzhou University,Changzhou 213164,China

State Key Laboratory of Coordination Chemistry,Nanjing University,Nanjing 210023,China

国家自然科学基金江苏省自然科学基金江苏省自然科学基金江苏省自然科学基金the"Young Scientists Lifting Project"of Jiangsu Province,China

U1904215BK20200044BK20190903BK20190905TJ-2022-072

2024

10.1016/j.cclet.2023.108821

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(5)
  • 150