Abstract
An efficient synthesis of the electrophilic reagent,S-(1,3-dioxoisoindolin-2-yl)O,O-diethyl phosphoroth-ioate(SDDP)is described.Moreover,the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)2 moiety occurs were investigated.In this manner,SDDP underwent facile SP(O)(OEt)2 transfer with electron-rich substrates such as ketones,indoles,and thiols to form α-phosphorothiolated ketones,3-phosphorothiolated indoles and S-phosphorothiolated thioethers,respectively.
基金项目
国家自然科学基金(21472133)
Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)()
Key Laboratory of Organic Synthesis of Jiangsu Province(KJS1749)
万方数据