首页|S-(1,3-Dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate(SDDP):A practical electrophilic reagent for the phosphorothiolation of electron-rich compounds
S-(1,3-Dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate(SDDP):A practical electrophilic reagent for the phosphorothiolation of electron-rich compounds
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An efficient synthesis of the electrophilic reagent,S-(1,3-dioxoisoindolin-2-yl)O,O-diethyl phosphoroth-ioate(SDDP)is described.Moreover,the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)2 moiety occurs were investigated.In this manner,SDDP underwent facile SP(O)(OEt)2 transfer with electron-rich substrates such as ketones,indoles,and thiols to form α-phosphorothiolated ketones,3-phosphorothiolated indoles and S-phosphorothiolated thioethers,respectively.
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