Abstract
The galactomannan from Antrodia cinnamomea(AC)is characterized as one of the important bioactive components that exhibits potential immunostimulatory propriety.The biological function of its corre-sponding oligosaccharide fragments has not been revealed yet.In this study,we reported the first chem-ical synthesis of the series of oligosaccharide fragments related to AC galactomannan via the convergent glycosylation strategy.The preliminary immunological evaluation of these synthesized AC oligosaccha-rides disclosed that the backbone tetrasaccharide 1d showed the best immunomodulatory ability on en-hancing proliferation,phagocytosis and cytokines secretion of Raw264.7 macrophages in vitro,indicating its immense potential as an immunostimulant candidate.
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