首页|Convergent synthesis and immunological study of oligosaccharide derivatives related to galactomannan from Antrodia cinnamomea
Convergent synthesis and immunological study of oligosaccharide derivatives related to galactomannan from Antrodia cinnamomea
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The galactomannan from Antrodia cinnamomea(AC)is characterized as one of the important bioactive components that exhibits potential immunostimulatory propriety.The biological function of its corre-sponding oligosaccharide fragments has not been revealed yet.In this study,we reported the first chem-ical synthesis of the series of oligosaccharide fragments related to AC galactomannan via the convergent glycosylation strategy.The preliminary immunological evaluation of these synthesized AC oligosaccha-rides disclosed that the backbone tetrasaccharide 1d showed the best immunomodulatory ability on en-hancing proliferation,phagocytosis and cytokines secretion of Raw264.7 macrophages in vitro,indicating its immense potential as an immunostimulant candidate.
National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University,Qingdao 266237,China
NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine,Shandong University,Qingdao 266237,China
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