首页|Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid
Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid
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维普
Multifunctional drug delivery systems(DDSs)have shown great prospects in overcoming the heteroge-neous barrier of delivery drugs to the complex tumor microenvironment(TME).In this study,multifunc-tional AS/Ge-pNAB microgels with dual-active targeting,triple environment responsiveness,and fluores-cence imaging capability were prepared through a straightforward procedure.This was aimed to improve the antitumor therapeutic application of gambogic acid(GA)based on the biological characteristics of TME.The microgels have a uniform double-layer structure with aptamer in the outer layer which helps in recognizing receptors on the tumor cells.The GA loaded nano-herb exhibited environment-responsive drug release profiles under acidic pH,reductant and high temperature.The nano-herb significantly im-proved the accumulation of GA in tumor sites through the synergistic combination of the enhanced per-meability and retention effect and dual-ligand mediated internalization.Then,it accelerated intracellular drug release and killed tumor cells.Therefore,the nano-herb had specific therapeutic effects on the tu-mor in vitro and in vivo as they remarkably inhibited tumor growth while depicting optimal biosafety and lower levels of off-target toxicity.Overall,these findings demonstrate the great potential of the mul-tifunctional AS/Ge-pNAB microgels for precisely targeted GA delivery and open a new avenue for the facile preparation of multifunctional DDSs.
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维普
