首页|Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death
Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death
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AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregation-induced emission(AIE)molecules have been developed and have evoked massive ICD in cells.However,due to the complex physicochemical environment in cells,these small AIE molecules cannot maintain a stable aggregate state,which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photo-sensitizer to elicit ICD.AIEgen-based nanomicelles,which maintain a stable micellar structure,can pre-vent defects of AIE molecules in photodynamic therapy(PDT)applications.Therefore,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.
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