Stabilization and detection of labile reaction intermediates in supramolecular containers

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外文摘要：Detection and observation of reactive intermediates is an essential step in investigation of reaction path-ways.However,most reactive intermediates are unstable and present at low concentrations;their short lifetimes make them difficult to detect and characterize.Supramolecular containers offer opportunities for the stabilization and characterization of those labile species,through isolation from the media and protection inside the cavity of the host.In this review,we summarize the examples of labile reaction intermediates that are stabilized and characterized with the help of supramolecular containers.The con-tainer compounds include carcerands,deep cavitands and amide naphthotubes.We focus on unstable guest species-cyclobutadiene,benzocyclopropenone,o-benzyne,1,2,4,6-cycloheptatetraene,anti-Bredt's olefin,fluorophenoxycarbene,O-acylisoamide,and hemiaminal-that act as intermediates in certain or-ganic reactions.

外文关键词：

Supramolecular containersReaction intermediatesLabile species stabilizationShort-lived species detectionSupramolecular chemistry

作者：

Rui Wang、Yang Liang、Julius Rebek Jr.、Yang Yu

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作者单位：

Center for Supramolecular Chemistry & Catalysis and Department of Chemistry,College of Science,Shanghai University,Shanghai 200444,China

Skaggs Institute for Chemical Biology and Department of Chemistry,The Scripps Research Institute,La Jolla,CA 92037,United States

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai Scientific and Technological Committee

项目编号：

220711442210116922010500300

出版年：

2024

DOI：

10.1016/j.cclet.2023.109228

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(6)