Abstract
Detection and observation of reactive intermediates is an essential step in investigation of reaction path-ways.However,most reactive intermediates are unstable and present at low concentrations;their short lifetimes make them difficult to detect and characterize.Supramolecular containers offer opportunities for the stabilization and characterization of those labile species,through isolation from the media and protection inside the cavity of the host.In this review,we summarize the examples of labile reaction intermediates that are stabilized and characterized with the help of supramolecular containers.The con-tainer compounds include carcerands,deep cavitands and amide naphthotubes.We focus on unstable guest species-cyclobutadiene,benzocyclopropenone,o-benzyne,1,2,4,6-cycloheptatetraene,anti-Bredt's olefin,fluorophenoxycarbene,O-acylisoamide,and hemiaminal-that act as intermediates in certain or-ganic reactions.
基金项目
National Natural Science Foundation of China(22071144)
National Natural Science Foundation of China(22101169)
Shanghai Scientific and Technological Committee(22010500300)
NETL
NSTL
万方数据