Strategies for constructing seven-membered rings:Applications in natural product synthesis

Peng Chen ¹Lijuan Liang ¹Yufei Zhu ¹Zhimin Xing ²Zhenhua Jia ³Teck-Peng Loh⁴

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作者信息

1. College of Advanced Interdisciplinary Science and Technology,Henan University of Technology,Zhengzhou 450001,China
2. State Key Laboratory of Applied Organic Chemistry,Department of Chemistry,Lanzhou University,Lanzhou 730000,China
3. College of Advanced Interdisciplinary Science and Technology,Henan University of Technology,Zhengzhou 450001,China;Division of Chemistry and Biological Chemistry,School of Chemistry Chemical Engineering,and Biotechnology,Nanyang Technological University,Singapore 637371,Singapore;Institute of Advanced Synthesis,School of Chemistry and Molecular Engineering Nanjing Tech University,Nanjing 211816,China
4. College of Advanced Interdisciplinary Science and Technology,Henan University of Technology,Zhengzhou 450001,China;Division of Chemistry and Biological Chemistry,School of Chemistry Chemical Engineering,and Biotechnology,Nanyang Technological University,Singapore 637371,Singapore
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Abstract

The seven-membered ring motifs are found in bioactive pharmaceuticals and a wide range of natural products,including alkaloids and terpenoids,which hold significant importance in synthetic chemistry and has garnered considerable attention from both academia and industry.Despite the challenges faced in the past decade,the total synthesis of natural products incorporating the non-aromatic cycloheptane skeletons remains a compelling pursuit.Recently,numerous elegant strategies for constructing the seven-membered ring system have been successfully developed.This review focuses on the recent advance-ments in this field from 2017 to April 2023,highlighting key transformations utilized to construct the non-aromatic cycloheptane core structures and serves as a valuable guide for synthetic chemists engaged in the total synthesis of natural products containing seven-membered ring motifs.

Key words

Seven-membered rings/Total synthesis/Natural products/Synthetic strategy/Cycloheptane

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基金项目

Startup Grant of Henan University of Technology(0004/31401540)

Distinguished University Professor Grant(Nanyang Technological University)()

AcRF Tier 1 grants from the Ministry of Education of Singapore(RG 107/19)

AcRF Tier 1 grants from the Ministry of Education of Singapore(RG 11/20)

AcRF Tier 1 grants from the Ministry of Education of Singapore(RT 14/20)

Agency for Science,Technology and Research(A*STAR)under its MTC Individual Research Grants(M21K2c0114)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量86

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