Strategies for constructing seven-membered rings:Applications in natural product synthesis

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外文摘要：The seven-membered ring motifs are found in bioactive pharmaceuticals and a wide range of natural products,including alkaloids and terpenoids,which hold significant importance in synthetic chemistry and has garnered considerable attention from both academia and industry.Despite the challenges faced in the past decade,the total synthesis of natural products incorporating the non-aromatic cycloheptane skeletons remains a compelling pursuit.Recently,numerous elegant strategies for constructing the seven-membered ring system have been successfully developed.This review focuses on the recent advance-ments in this field from 2017 to April 2023,highlighting key transformations utilized to construct the non-aromatic cycloheptane core structures and serves as a valuable guide for synthetic chemists engaged in the total synthesis of natural products containing seven-membered ring motifs.

外文关键词：

Seven-membered ringsTotal synthesisNatural productsSynthetic strategyCycloheptane

作者：

Peng Chen、Lijuan Liang、Yufei Zhu、Zhimin Xing、Zhenhua Jia、Teck-Peng Loh

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作者单位：

College of Advanced Interdisciplinary Science and Technology,Henan University of Technology,Zhengzhou 450001,China

State Key Laboratory of Applied Organic Chemistry,Department of Chemistry,Lanzhou University,Lanzhou 730000,China

Division of Chemistry and Biological Chemistry,School of Chemistry Chemical Engineering,and Biotechnology,Nanyang Technological University,Singapore 637371,Singapore

Institute of Advanced Synthesis,School of Chemistry and Molecular Engineering Nanjing Tech University,Nanjing 211816,China

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基金：

Startup Grant of Henan University of TechnologyDistinguished University Professor Grant(Nanyang Technological University)AcRF Tier 1 grants from the Ministry of Education of SingaporeAcRF Tier 1 grants from the Ministry of Education of SingaporeAcRF Tier 1 grants from the Ministry of Education of SingaporeAgency for Science,Technology and Research(A*STAR)under its MTC Individual Research Grants

项目编号：

0004/31401540RG 107/19RG 11/20RT 14/20M21K2c0114

出版年：

2024

DOI：

10.1016/j.cclet.2023.109229

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(6)