Triphenylamine-AIEgens photoactive materials for cancer theranostics

Junjie Wang ¹Yan Wang ²Zhengdong Li ³Changqiang Xie ²Musammir Khan ⁴Xingzhou Peng ²Fabiao Yu¹

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作者信息

1. Key Laboratory of Hainan Trauma and Disaster Rescue,The First Affiliated Hospital of Hainan Medical University,Hainan Medical University,Haikou 571199,China;Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices,Key Laboratory of Emergency and Trauma,Ministry of Education,Key Laboratory of Hainan Functional Materials and Molecular Imaging,College of Emergency and Trauma,Hainan Medical University,Haikou 571199,China
2. State Key Laboratory of Digital Medical Engineering,School of Biomedical Engineering,Hainan University,Haikou 570228,China;Key Laboratory of Biomedical Engineering of Hainan Province,One Health Institute,Hainan University,Haikou 570228,China
3. Precision Medical Center,Guangyuan City Centre hospital,Guangyuan 628099,China
4. School of Natural Sciences(SNS),National University of Science and Technology(NUST),H-12,Islamabad 44000,Pakistan
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Abstract

Triphenylamine(TPA)-based aggregation-induced emission luminogens(TPA-AIEgens),a type of photoac-tive material utilizing the typical TPA moiety,has recently attracted increasing attention for the diag-nostics and treatment of tumors due to their remarkable chemo-physical performance in optoelectronic research.TPA-AIEgens are distinguished from other photoactive agents by their strong fluorescence,good sensitivity,high signal-to-noise ratio,resistance to photobleaching,and lack of high concentration or aggregation-caused fluoresce quenching effects.In this review,we summarize the current advancements and the biomedical progress of TPA-AIEgens in tumor theranostics.First,the design principles of TPA-AIEgens photoactive agents as well as the advanced targeting strategies for nuclei,cell membranes,cell organelle and tumors were introduced,respectively.Next,the applications of TPA-AIEgens in tumor di-agnosis and therapeutic techniques were reviewed.Last,the challenges and prospects of TPA-AIEgens for cancer therapy were performed.The given landscape of the TPA-AIEgens hereby is meaningful for the further design and utilization of the novel photoactive material,which could be beneficial for the devel-opment of clinic applications.

Key words

Triphenylamine/AIEgens/Targeting/Theranostics/Phototherapy/Immunotherapy

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基金项目

Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City(820LH027)

Hainan Provincial Natural Science Foundation of China(823RC472)

Open Project Program of Wuhan National Laboratory for Optoelectronics(2021WNLOKF008)

Hainan University Scientific Research Foundation(KYQDZR19107)

Natural Science Research Talent Project of Hainan Medical University(JBGS202101)

Hainan Province Clinical Medical Center(2021)()

Project for Functional Materials and Molecular Imaging Science Innovation Group of Hainan Medical University()

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量119

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