Triphenylamine-AIEgens photoactive materials for cancer theranostics

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外文摘要：Triphenylamine(TPA)-based aggregation-induced emission luminogens(TPA-AIEgens),a type of photoac-tive material utilizing the typical TPA moiety,has recently attracted increasing attention for the diag-nostics and treatment of tumors due to their remarkable chemo-physical performance in optoelectronic research.TPA-AIEgens are distinguished from other photoactive agents by their strong fluorescence,good sensitivity,high signal-to-noise ratio,resistance to photobleaching,and lack of high concentration or aggregation-caused fluoresce quenching effects.In this review,we summarize the current advancements and the biomedical progress of TPA-AIEgens in tumor theranostics.First,the design principles of TPA-AIEgens photoactive agents as well as the advanced targeting strategies for nuclei,cell membranes,cell organelle and tumors were introduced,respectively.Next,the applications of TPA-AIEgens in tumor di-agnosis and therapeutic techniques were reviewed.Last,the challenges and prospects of TPA-AIEgens for cancer therapy were performed.The given landscape of the TPA-AIEgens hereby is meaningful for the further design and utilization of the novel photoactive material,which could be beneficial for the devel-opment of clinic applications.

外文关键词：

TriphenylamineAIEgensTargetingTheranosticsPhototherapyImmunotherapy

作者：

Junjie Wang、Yan Wang、Zhengdong Li、Changqiang Xie、Musammir Khan、Xingzhou Peng、Fabiao Yu

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作者单位：

Key Laboratory of Hainan Trauma and Disaster Rescue,The First Affiliated Hospital of Hainan Medical University,Hainan Medical University,Haikou 571199,China

Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices,Key Laboratory of Emergency and Trauma,Ministry of Education,Key Laboratory of Hainan Functional Materials and Molecular Imaging,College of Emergency and Trauma,Hainan Medical University,Haikou 571199,China

State Key Laboratory of Digital Medical Engineering,School of Biomedical Engineering,Hainan University,Haikou 570228,China

Key Laboratory of Biomedical Engineering of Hainan Province,One Health Institute,Hainan University,Haikou 570228,China

Precision Medical Center,Guangyuan City Centre hospital,Guangyuan 628099,China

School of Natural Sciences(SNS),National University of Science and Technology(NUST),H-12,Islamabad 44000,Pakistan

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基金：

Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology CityHainan Provincial Natural Science Foundation of ChinaOpen Project Program of Wuhan National Laboratory for OptoelectronicsHainan University Scientific Research FoundationNatural Science Research Talent Project of Hainan Medical UniversityHainan Province Clinical Medical Center(2021)Project for Functional Materials and Molecular Imaging Science Innovation Group of Hainan Medical University

项目编号：

820LH027823RC4722021WNLOKF008KYQDZR19107JBGS202101

出版年：

2024

DOI：

10.1016/j.cclet.2023.108934

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(6)