Abstract
Exhaled ammonia(NH3)can be used as a crucial biomarker of kidney and liver diseases.However,the high humidity in the detection conditions remains a challenge for accurate detection by gas sensors.Herein,a copper-based metal-organic framework(CH3-Cu-BTC)with methyl(CH3-)functionalization of trimesic acid was synthesized for NH3 colorimetric sensing.The CH3-Cu-BTC exhibited a strong response for 5 ppm NH3 with high selectivity under high relative humidity(75％RH).Density functional theory(DFT)simulations indicated that the NH3 molecules interacted more strongly with CH3-Cu-BTC than H2O molecules did,and the corresponding color switching was attributed to the lone-pair electron in NH3 changing the coordination environment of Cu2+ions,leading to an obviously visible color switching re-sponse from ruby green to blue.Based on the tailor-made pore chemistry,the precise detection of trace amounts of NH3 in exhaled air was realized through functionalized MOF materials.The strategy used in this study not only offers a new pathway for the rapid detection of low concentration NH3 under humid conditions,but also shows a method for early respiration diagnosis of kidney and liver diseases.
基金项目
National Natural Science Foundation of China(22090062)
National Natural Science Foundation of China(22278287)
National Natural Science Foundation of China(22278288)
Shanxi Province 136 Revitalization Medical Project(General Surgery Department)()
Shanxi Provincial Guiding Science and Technology Special Project(2021XM42)
Basic Research Program of Shanxi Province(202103021224341)
NETL
NSTL
万方数据