Abstract
Glycosyl radicals,produced under mild photoredox conditions,show unique utility in the preparation of C-linked glycoconjugates.We herein report the construction of C-glycosidic bonds on α,β-dehydroalanine(DHA)of peptides with easily available glycosyl bromides as glycosyl radical precursors under highly anomeric control,leading to C-glycosylation modifications of peptides.This method not only has out-standing functional group compatibility,but also is feasible in near-physiological conditions(pH～7 and temperature T ≤ 37 ℃ in aqueous media).
基金项目
National Natural Science Foundation of China(22171133)
State Key Laboratory of Analytical Chemistry for Life Science(5431ZZXM2308)
NETL
NSTL
万方数据