首页|Photoredox-catalyzed C-glycosylation of peptides with glycosyl bromides
Photoredox-catalyzed C-glycosylation of peptides with glycosyl bromides
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Glycosyl radicals,produced under mild photoredox conditions,show unique utility in the preparation of C-linked glycoconjugates.We herein report the construction of C-glycosidic bonds on α,β-dehydroalanine(DHA)of peptides with easily available glycosyl bromides as glycosyl radical precursors under highly anomeric control,leading to C-glycosylation modifications of peptides.This method not only has out-standing functional group compatibility,but also is feasible in near-physiological conditions(pH～7 and temperature T ≤ 37 ℃ in aqueous media).
State Key Laboratory of Analytical Chemistry for Life Science,Jiangsu Key Laboratory of Advanced Organic Materials,Chemistry and Biomedicine Innovation Center(ChemBIC),School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China
National Natural Science Foundation of ChinaState Key Laboratory of Analytical Chemistry for Life Science
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