Macrocycle confinement induced guest near-infrared(NIR)luminescence was research hotspot cur-rently.Here in,we reported a cucurbit[7]uril(CB[7])confined 3,7-bis((E)-2-(pyridin-4-yl)vinyl)-10-H-phenothiazine bridged bis(4-(4-bromophenyl)pyridine)(G),which not only boosted its NIR luminescence but also realized detection of HClO/ClO-in living cells and lysosome imaging.Fluorescence spectroscopy experiments were performed to calculate the detection ability of probe G to HClO/ClO-up to 147 nmol/L.As compared with G,supramolecular probe G(C)CB[7]formed after encapsulated by CB[7],the detec-tion ability towards HClO/ClO-was improved to 24 nmol/L which was ascribe to the macrocycle CB[7]confinement increasing the fluorescence intensity to 103 folds.Accompanying the excitation wavelength changing,the fluorescence red-shifted to 820 nm when excited by 570 nm light,which was used to NIR lysosome imaging.Meanwhile,the supramolecular assembly G(C)CB[7]was also successfully used to highly sense to exogenous HClO/ClO-in RAW 264.7 cells and live animal.
Hui-Juan Wang、Wen-Wen Xing、Zhen-Hai Yu、Yong-Xue Li、Heng-Yi Zhang、Qilin Yu、Hongjie Zhu、Yao-Yao Wang、Yu Liu
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College of Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology,School of Chemistry and Chemical Engineering,Liaocheng University,Liaocheng 252000,China
Key Laboratory of Molecular Microbiology and Technology,College of Life Sciences,Nankai University,Tianjin 300071,China
National Natural Science Foundation of ChinaLiaocheng University Startup Fund for Doctoral Scientific ResearchAnimal Experimentation Ethics Committee of Nankai University
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