Abstract
Macrocycle confinement induced guest near-infrared(NIR)luminescence was research hotspot cur-rently.Here in,we reported a cucurbit[7]uril(CB[7])confined 3,7-bis((E)-2-(pyridin-4-yl)vinyl)-10-H-phenothiazine bridged bis(4-(4-bromophenyl)pyridine)(G),which not only boosted its NIR luminescence but also realized detection of HClO/ClO-in living cells and lysosome imaging.Fluorescence spectroscopy experiments were performed to calculate the detection ability of probe G to HClO/ClO-up to 147 nmol/L.As compared with G,supramolecular probe G(C)CB[7]formed after encapsulated by CB[7],the detec-tion ability towards HClO/ClO-was improved to 24 nmol/L which was ascribe to the macrocycle CB[7]confinement increasing the fluorescence intensity to 103 folds.Accompanying the excitation wavelength changing,the fluorescence red-shifted to 820 nm when excited by 570 nm light,which was used to NIR lysosome imaging.Meanwhile,the supramolecular assembly G(C)CB[7]was also successfully used to highly sense to exogenous HClO/ClO-in RAW 264.7 cells and live animal.
基金项目
National Natural Science Foundation of China(22131008)
Liaocheng University Startup Fund for Doctoral Scientific Research(318052327)
Animal Experimentation Ethics Committee of Nankai University(2021-SYDELL-000448)
NETL
NSTL
万方数据