Abstract
Single-chain nanoparticles represent an emerging class of nanomaterials designed to mimic protein's fold-ing paradigm.Intrachain covalent crosslinking toward the formation of single-chain nanoparticles encoun-ters complex energy landscapes,leading to the potential occurrence of misfolding issues.While non-covalent crosslinking can circumvent this issue,the resulting single-chain nanoparticles exhibit lower structural stability compared to their covalently crosslinked counterparts.In this study,we present a novel approach for the synthesis of single-chain nanoparticles,achieved through the combination of non-covalent and covalent intramolecular crosslinking.Cyanostilbenes grafted onto the linear polymer form intrachain non-covalent stacks aided by hydrogen bonds,leading to the formation of non-covalently crosslinked single-chain nanoparticles.These nanoparticles undergo conversion to covalently crosslinked nanostructures through subsequent photo-irradiation using[2+2]photocycloaddition,a process facili-tated by the supramolecular confinement effect.Consequently,the resulting single-chain nanoparticles demonstrate both intrachain folding efficiency and substantial stability,offering significant potential for advancing applications across diverse fields.
基金项目
National Natural Science Foundation of China(22371272)
National Natural Science Foundation of China(22301295)
Fundamental Research Funds for the Central Universities(YD2060002036)
Fundamental Research Funds for the Central Universities(WK5290000004)
International Partnership Program of the Chinese Academy of Sciences(123GJHZ2022064MI)
Collaborative Innovation Program of Hefei Science Center,CAS(2022HSC-CIP014)
NETL
NSTL
万方数据