首页|Merging non-covalent and covalent crosslinking:En route to single chain nanoparticles

Merging non-covalent and covalent crosslinking:En route to single chain nanoparticles

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Single-chain nanoparticles represent an emerging class of nanomaterials designed to mimic protein's fold-ing paradigm.Intrachain covalent crosslinking toward the formation of single-chain nanoparticles encoun-ters complex energy landscapes,leading to the potential occurrence of misfolding issues.While non-covalent crosslinking can circumvent this issue,the resulting single-chain nanoparticles exhibit lower structural stability compared to their covalently crosslinked counterparts.In this study,we present a novel approach for the synthesis of single-chain nanoparticles,achieved through the combination of non-covalent and covalent intramolecular crosslinking.Cyanostilbenes grafted onto the linear polymer form intrachain non-covalent stacks aided by hydrogen bonds,leading to the formation of non-covalently crosslinked single-chain nanoparticles.These nanoparticles undergo conversion to covalently crosslinked nanostructures through subsequent photo-irradiation using[2+2]photocycloaddition,a process facili-tated by the supramolecular confinement effect.Consequently,the resulting single-chain nanoparticles demonstrate both intrachain folding efficiency and substantial stability,offering significant potential for advancing applications across diverse fields.

Single chain nanoparticlesIntrachain foldingSupramolecular confinementCyanostilbenes[2+2]photocycloaddition

Yifei Zhang、Yuncong Xue、Laiwei Gao、Rui Liao、Feng Wang、Fei Wang

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CAS Key Laboratory of Soft Matter Chemistry,Department of Polymer Science and Engineering,University of Science and Technology of China,Hefei 230026,China

Department of Neurosurgical,The First Affiliated Hospital of University of Science and Technology of China,Division of Life Sciences and Medicine,Hefei 230026,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaFundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central UniversitiesInternational Partnership Program of the Chinese Academy of SciencesCollaborative Innovation Program of Hefei Science Center,CAS

2237127222301295YD2060002036WK5290000004123GJHZ2022064MI2022HSC-CIP014

2024

10.1016/j.cclet.2023.109217

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(6)
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