Pd(Ⅰ)-catalyzed ring-opening arylation of cyclopropyl-α-aminoamides:Access to α-ketoamide peptidomimetics
Yue Sun 1Liming Yang 1Yaohang Cheng 1Guanghui An 1Guangming Li1
作者信息
- 1. School of Chemistry and Materials Science,Heilongjiang University,Harbin 150080,China
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Abstract
We report the unprecedent Pd(Ⅰ)catalyzed ring-opening arylation of cyclopropyl-α-aminoamides.This protocol allows facile access to biologically important α-ketoamide-containing oligopeptides and even more challenging peptide-natural product conjugates.Site selectivity was achieved by introduction of special unnatural amino acids,which also meets the requisite of bioorthogonal chemistry.Mechanism investigations reveals a distinct domino radical ring-opening process through Pd(l)catalysis.
Key words
Pd(Ⅰ)catalysis/Ring-opening arylation/Domino reactions/Oligopeptides/Late-stage functionalization引用本文复制引用
基金项目
University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province(UNPYSCT-2017124)
出版年
2024
NETL
NSTL
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