首页|Pd(Ⅰ)-catalyzed ring-opening arylation of cyclopropyl-α-aminoamides:Access to α-ketoamide peptidomimetics
Pd(Ⅰ)-catalyzed ring-opening arylation of cyclopropyl-α-aminoamides:Access to α-ketoamide peptidomimetics
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We report the unprecedent Pd(Ⅰ)catalyzed ring-opening arylation of cyclopropyl-α-aminoamides.This protocol allows facile access to biologically important α-ketoamide-containing oligopeptides and even more challenging peptide-natural product conjugates.Site selectivity was achieved by introduction of special unnatural amino acids,which also meets the requisite of bioorthogonal chemistry.Mechanism investigations reveals a distinct domino radical ring-opening process through Pd(l)catalysis.
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