中国化学快报(英文版)2024，Vol.35Issue(6) ：331-336.DOI:10.1016/j.cclet.2023.109263

Photoinduced copper-catalyzed alkoxyl radical-triggered ring-expansion/aminocarbonylation cascade

Jing-Qi Tao Shuai Liu Tian-Yu Zhang Hong Xin Xu Yang Xin-Hua Duan Li-Na Guo
中国化学快报(英文版)2024，Vol.35Issue(6) ：331-336.DOI:10.1016/j.cclet.2023.109263
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Photoinduced copper-catalyzed alkoxyl radical-triggered ring-expansion/aminocarbonylation cascade

Jing-Qi Tao 1Shuai Liu 1Tian-Yu Zhang 1Hong Xin 1Xu Yang 2Xin-Hua Duan 3Li-Na Guo1
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作者信息

  • 1. Department of Chemistry,School of Chemistry,Xi'an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy Storage Materials and Devices,Ministry of Education,Xi'an Jiaotong University,Xi'an 710049,China
  • 2. School of Electrical Engineering,Xi'an Jiaotong University,Xi'an 710049,China
  • 3. Department of Chemistry,School of Chemistry,Xi'an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy Storage Materials and Devices,Ministry of Education,Xi'an Jiaotong University,Xi'an 710049,China;State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000,China
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Abstract

A photoinduced copper-catalyzed alkoxyl triggered C-C bond cleavage/aminocarbonylation cascade is presented.Through adjusting the structure of alkoxyl radical precursors,functionalized lactones and keto-amides were synthesized with good yields and excellent functional group tolerance under redox-neutral conditions.Notably,this protocol enables the integration of lactone fragments with many amine drugs and drug fragments.

Key words

Copper catalysis/Ring-expansion/Aminocarbonylatioin/Macrolactones/Keto-amides

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基金项目

National Natural Science Foundation of China(21971201)

National Natural Science Foundation of China(22171220)

Fundamental Research Funds of the Central Universities(xtr072022003)

出版年

2024
中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCDCSCD
影响因子：0.771
ISSN：1001-8417
参考文献量50
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