A photoinduced copper-catalyzed alkoxyl triggered C-C bond cleavage/aminocarbonylation cascade is presented.Through adjusting the structure of alkoxyl radical precursors,functionalized lactones and keto-amides were synthesized with good yields and excellent functional group tolerance under redox-neutral conditions.Notably,this protocol enables the integration of lactone fragments with many amine drugs and drug fragments.
Department of Chemistry,School of Chemistry,Xi'an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy Storage Materials and Devices,Ministry of Education,Xi'an Jiaotong University,Xi'an 710049,China
School of Electrical Engineering,Xi'an Jiaotong University,Xi'an 710049,China
State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000,China
National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaFundamental Research Funds of the Central Universities
NETL
NSTL
万方数据
