Abstract
Integrating ring-fused modification with π-conjugated extension is an effective approach for designing,synthesizing,and application for novel borondipyrromethene(BODIPY)structures.In this work,based on phenyl[b]-fused BODIPY,we made reasonable modification of the methyl group at 1-site to gener-ate dye NBDP.NBDP possessed near-infrared region(NIR)absorption and emission properties,and the intramolecular charge transfer(ICT)resulted in low fluorescence.Whereas,heat energy is evidently re-leased in the presence of light,which can be exploited for intracellular photothermal therapy via the cell apoptosis process,reducing the inflammatory side-effects induced by necrosis.This research provides a crucial foundation for the novel molecule via BODIPY multi-directional alteration and its potential appli-cation in anti-tumor phototherapy.
基金项目
National Natural Science Foundation of China(22078201)
National Natural Science Foundation of China(U1908202)
Natural Science Foundation of Liaoning(2021NLTS1206)
"Chunhui Program"cooperative research project of Education Ministry,Liaoning &Shenyang Key Laboratory of Functional Dye and Pigm(2021JH13/10200018)
"Chunhui Program"cooperative research project of Education Ministry,Liaoning &Shenyang Key Laboratory of Functional Dye and Pigm(21-104-0-23)
NETL
NSTL
万方数据