首页|Development of functional dye with redshifted absorption based on Knoevenagel condensation at 1-site in phenyl[b]-fused BODIPY

Development of functional dye with redshifted absorption based on Knoevenagel condensation at 1-site in phenyl[b]-fused BODIPY

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Integrating ring-fused modification with π-conjugated extension is an effective approach for designing,synthesizing,and application for novel borondipyrromethene(BODIPY)structures.In this work,based on phenyl[b]-fused BODIPY,we made reasonable modification of the methyl group at 1-site to gener-ate dye NBDP.NBDP possessed near-infrared region(NIR)absorption and emission properties,and the intramolecular charge transfer(ICT)resulted in low fluorescence.Whereas,heat energy is evidently re-leased in the presence of light,which can be exploited for intracellular photothermal therapy via the cell apoptosis process,reducing the inflammatory side-effects induced by necrosis.This research provides a crucial foundation for the novel molecule via BODIPY multi-directional alteration and its potential appli-cation in anti-tumor phototherapy.

NIR dyes[b]-Fused BODIPYKnoevenagel condensationPhotothermal therapyCell apoptosis

Tianze Wang、Junyi Ren、Dongxiang Zhang、Huan Wang、Jianjun Du、Xin-Dong Jiang、Guiling Wang

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Liaoning & Shenyang Key Laboratory of Functional Dye and Pigment,Shenyang University of Chemical Technology,Shenyang 110142,China

Department of Cell Biology,China Medical University,Shenyang 110122,China

State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Liaoning"Chunhui Program"cooperative research project of Education Ministry,Liaoning &Shenyang Key Laboratory of Functional Dye and Pigm"Chunhui Program"cooperative research project of Education Ministry,Liaoning &Shenyang Key Laboratory of Functional Dye and Pigm

22078201U19082022021NLTS12062021JH13/1020001821-104-0-23

2024

10.1016/j.cclet.2023.108862

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(6)
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