首页|Discovery of unusual phloroglucinol-triterpenoid adducts from Leptospermum scoparium and Xanthostemon chrysanthus by building blocks-based molecular networking

Discovery of unusual phloroglucinol-triterpenoid adducts from Leptospermum scoparium and Xanthostemon chrysanthus by building blocks-based molecular networking

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The first phloroglucinol-triterpenoid hybrids,myrtphlotritins A-E(1-5),were rapidly recognized and iso-lated from two species of Myrtaceae by employing the building blocks-based molecular network(BBMN)strategy.Compounds 1-5 featured new carbon skeletons in which phloroglucinol derivatives were cou-pled with lupane-and dammarane-type triterpenoids through different linkage patterns.Their structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and quan-tum chemical calculations.Biosynthetic pathways for compounds 1-5 were proposed on the basis of the coexisting precursors.Guided by the biogenetic pathways,the biomimetic synthesis of compound 1 was also achieved.Additionally,compounds 2,3,and 5 exhibited potent antiviral activities against herpes simplex virus type-1(HSV-1)infection,and compounds 2 and 5 displayed significant anti-inflammatory activities on RAW264.7 cells.

Phloroglucinol-triterpenoid adductMyrtaceaeBuilding blocks-based molecular networkBiomimetic synthesisAntiviral activityAnti-inflammatory activity

Jinyan Zhang、Fen Liu、Qian Jin、Xueyi Li、Qiong Zhan、Mu Chen、Sisi Wang、Zhenlong Wu、Wencai Ye、Lei Wang

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State Key Laboratory of Bioactive Molecules and Druggability Assessment,Jinan University,Guangzhou 510632,China

Center for Bioactive Natural Molecules and Innovative Drugs,and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Jinan University,Guangzhou 510632,China

College of Pharmacy,Jinan University,Guangzhou 510632,China

Guangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationNational Natural Science Foundation of ChinaLocal Innovative and Research Teams Project of Guangdong Pearl River Talents ProgramFundamental Research Funds for the Central Universities

2020B15151200662022A15150100102020B11111100042017BT01Y036

2024

10.1016/j.cclet.2023.108881

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(6)
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