Abstract
The first phloroglucinol-triterpenoid hybrids,myrtphlotritins A-E(1-5),were rapidly recognized and iso-lated from two species of Myrtaceae by employing the building blocks-based molecular network(BBMN)strategy.Compounds 1-5 featured new carbon skeletons in which phloroglucinol derivatives were cou-pled with lupane-and dammarane-type triterpenoids through different linkage patterns.Their structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and quan-tum chemical calculations.Biosynthetic pathways for compounds 1-5 were proposed on the basis of the coexisting precursors.Guided by the biogenetic pathways,the biomimetic synthesis of compound 1 was also achieved.Additionally,compounds 2,3,and 5 exhibited potent antiviral activities against herpes simplex virus type-1(HSV-1)infection,and compounds 2 and 5 displayed significant anti-inflammatory activities on RAW264.7 cells.
基金项目
Guangdong Basic and Applied Basic Research Foundation(2020B1515120066)
Guangdong Basic and Applied Basic Research Foundation(2022A1515010010)
National Natural Science Foundation of China(2020B1111110004)
Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036)
Fundamental Research Funds for the Central Universities()
NETL
NSTL
万方数据