Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration

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外文摘要：Surface modification of microporous bone scaffolds using nanoparticles has been broadly studied in bone tissue engineering.Aiming at improving vascularized bone regeneration(VBR),zeolitic imidazo-late framework-8(ZIF-8)was encapsulated with dimethyloxallyl glycine(DMOG)and the drug-carrying nanoparticles(D@Z)could be uniformly coated onto the surface of the bone scaffold.The osteogenic and angiogenic actions of D@Z are closely correlated with the amount of slowly released DMOG,and in general,exhibited a favorable association.Then,the D7.5@Z group,which showed the greatest capacity to induce in vitro osteogenesis-angiogenesis coupling,was utilized for surface modification of the bone scaffold.Biological processes including phosphate-containing compound metabolic process,cell differen-tiation,cell proliferation and cell motility might contribute to enhanced ability to induce VBR by the coated scaffold and signaling pathways such as Rap1,Ras,phosphatidylinositol 3-kinase/protein kinase B(PI3K-AKT)and vascular endothelial growth factor(VEGF)signaling pathways participated in these pro-cesses.Finally,as depicted by in vitro real time-polymerase chain reaction(RT-PCR),Western blot(WB)and in vivo cranial bone defect model,the microporous scaffold coated with nano-D7.5@Z greatly pro-moted VBR.To conclude,nano-D@Z has significant promise for practical application in modification of microporous bone scaffolds to enhance VBR,and DMOG loading quantity has a beneficial influence on D@Z to improve osteogenesis-angiogenesis coupling.

外文关键词：

Drug-loading nanoparticlesSurface coatingMicroporous bone scaffoldVascularizationbone regeneration

作者：

Xin Zhang、Junyu Chen、Xiang Pei、Linxin Yang、Liang Wang、Luona Chen、Guangmei Yang、Xibo Pei、Qianbing Wan、Jian Wang

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作者单位：

State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Chengdu 610041,China

Department of Prosthodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaSpecial Funding for Postdoctoral Research Projects in Sichuan ProvinceSichuan Province Science and Technology Plan ProjectsChina Postdoctoral Science FoundationResearch and Development Program(West China Hospital of Stomatology Sichuan University)Research and Development Program(West China Hospital of Stomatology Sichuan University)

项目编号：

8220112882271034TB202204523NSFSC17232022M722250RD-02-2022012RD-03-202107

出版年：

2024

DOI：

10.1016/j.cclet.2023.108889

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(6)