Abstract
Abnormal accumulation and metabolism of lipid droplets can lead to a variety of diseases.Polarity,a key parameter of the microenvironment,is closely associated with many diseases and dysfunctions in the body.It is important to elucidate the relationship between the physiological activity of lipid droplets(LDs)and the polarity of the microenvironment.In this work,based on push-pull mechanism,a fluorescent probe(E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one(PPTH)with aggregation-induced emission(AIE)properties for the detection of polarity changes in cells was synthesized.PPTH not only visualize intracellular polarity fluctuation of iron death and inflam-mation but also distinguish between normal and fatty liver tissue.
基金项目
Scientific and Technological Key Project in Henan Province(22170015)
National Natural Science Foundation of China(U1704161)
Zhengzhou University(32211807)
Henan Provincial Science and Technology Research Project(JC21253010)
Basic Research Foundation of Shenzhen Science and Technology Innovation(JCYJ20190806144605441)
NETL
NSTL
万方数据