首页|A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death,inflammation and fatty liver tissue

A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death,inflammation and fatty liver tissue

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Abnormal accumulation and metabolism of lipid droplets can lead to a variety of diseases.Polarity,a key parameter of the microenvironment,is closely associated with many diseases and dysfunctions in the body.It is important to elucidate the relationship between the physiological activity of lipid droplets(LDs)and the polarity of the microenvironment.In this work,based on push-pull mechanism,a fluorescent probe(E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one(PPTH)with aggregation-induced emission(AIE)properties for the detection of polarity changes in cells was synthesized.PPTH not only visualize intracellular polarity fluctuation of iron death and inflam-mation but also distinguish between normal and fatty liver tissue.

Lipid dropletsAIEPolarityFerroptosisFatty liver

Xing Tian、Di Wu、Wanheng Wei、Guifu Dai、Zhanxian Li、Benhua Wang、Mingming Yu

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Green Catalysis Center and College of Chemistry,Zhengzhou University,Zhengzhou 450001,China

School of Life Sciences,Zhengzhou University,Zhengzhou 450001,China

Shenzhen Research Institute of Central South University,Shenzhen 518057,China

Scientific and Technological Key Project in Henan ProvinceNational Natural Science Foundation of ChinaZhengzhou UniversityHenan Provincial Science and Technology Research ProjectBasic Research Foundation of Shenzhen Science and Technology Innovation

22170015U170416132211807JC21253010JCYJ20190806144605441

2024

10.1016/j.cclet.2023.108912

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(6)