首页|Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

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Three novel matrine-type alkaloids(1-3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides respectively.Notably,compound 1 possessed an unprecedented 6/5/6 tricyclic skeleton,while compounds 2 and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system respectively.Moreover,compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core,and compound 5 characterized by rare 6/6/6/6 tetracyclic skeleton.Their structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism(ECD)calculations.Biological tests indicated that compound 5 displayed sig-nificant anti-tobacco mosaic virus(TMV)activity compared with the positive control ningnanmycin.

Matrine-type alkaloidsAloperine-type alkaloidsSophora tonkinensisSophora alopecuroidesAnti-tobacco mosaic virus

Ji Zhang、Tong Zhang、Qiao An、Peng Zhang、Cai-Yan Tian、Chun-Mao Yuan、Ping Yi、Zhan-Xing Hu、Xiao-Jiang Hao

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State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550014,China

Natural Products Research Center of Guizhou Province,Guiyang 550014,China

School of Pharmaceutical Sciences,Guizhou Medical University,Guiyang 550025,China

School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China

State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Science,Kunming 650201,China

Research Unit of Chemical Biology of Natural Anti-Virus Products,Chinese Academy of Medical Sciences,Kunming 650201,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScience and Technology Department of Guizhou ProvinceScience and Technology Department of Guizhou ProvinceScience and Technology Department of Guizhou ProvinceGuizhou Provincial Engineering Research Center for Natural Drugs

32160103U1812403QKH ZC-[2021]-YB181QKH CXTD-[2022]-007QKH ZYD-[2022]-4015

2024

10.1016/j.cclet.2023.108927

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(6)
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