中国化学快报(英文版)2024，Vol.35Issue(6) ：380-384.DOI:10.1016/j.cclet.2023.108927

Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

Ji Zhang Tong Zhang Qiao An Peng Zhang Cai-Yan Tian Chun-Mao Yuan Ping Yi Zhan-Xing Hu Xiao-Jiang Hao
中国化学快报(英文版)2024，Vol.35Issue(6) ：380-384.DOI:10.1016/j.cclet.2023.108927
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Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

Ji Zhang 1Tong Zhang 1Qiao An 2Peng Zhang 2Cai-Yan Tian 3Chun-Mao Yuan 2Ping Yi 2Zhan-Xing Hu 2Xiao-Jiang Hao4
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作者信息

  • 1. State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550014,China;Natural Products Research Center of Guizhou Province,Guiyang 550014,China;School of Pharmaceutical Sciences,Guizhou Medical University,Guiyang 550025,China
  • 2. State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550014,China;Natural Products Research Center of Guizhou Province,Guiyang 550014,China
  • 3. State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550014,China;Natural Products Research Center of Guizhou Province,Guiyang 550014,China;School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China
  • 4. State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550014,China;Natural Products Research Center of Guizhou Province,Guiyang 550014,China;State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Science,Kunming 650201,China;Research Unit of Chemical Biology of Natural Anti-Virus Products,Chinese Academy of Medical Sciences,Kunming 650201,China
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Abstract

Three novel matrine-type alkaloids(1-3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides respectively.Notably,compound 1 possessed an unprecedented 6/5/6 tricyclic skeleton,while compounds 2 and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system respectively.Moreover,compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core,and compound 5 characterized by rare 6/6/6/6 tetracyclic skeleton.Their structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism(ECD)calculations.Biological tests indicated that compound 5 displayed sig-nificant anti-tobacco mosaic virus(TMV)activity compared with the positive control ningnanmycin.

Key words

Matrine-type alkaloids/Aloperine-type alkaloids/Sophora tonkinensis/Sophora alopecuroides/Anti-tobacco mosaic virus

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基金项目

National Natural Science Foundation of China(32160103)

National Natural Science Foundation of China(U1812403)

Science and Technology Department of Guizhou Province(QKH ZC-[2021]-YB181)

Science and Technology Department of Guizhou Province(QKH CXTD-[2022]-007)

Science and Technology Department of Guizhou Province(QKH ZYD-[2022]-4015)

Guizhou Provincial Engineering Research Center for Natural Drugs()

出版年

2024
中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
参考文献量3
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