A highly sensitive fluorescent HClO probe for discrimination between cancerous and normal cells/tissues

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外文摘要：Elevated level of hypochlorous acid(HClO)is closely associated with cancer development.Identifying HClO level in cancer cells would provide important evidence in either early-stage cancer diagnostics or monitoring of its treatment efficiency.In this work,a new pyronine-based fluorescent probe for rapid and sensitive detection of HClO was developed by condensing meso-formyl pyronine(PyCHO)with 2-hydrazinopyridine to form meso-pyridylhydrazone-functionalized pyronine PyHP,PyHP is nonfluorescent due to the excited-state C=N isomerization nonradiative decay,whereas the HClO-triggered formation of meso-triazolopyridyl pyronine PyTP abolishes the C=N isomerization and thus greatly enhances the fluorescence.With the probe,the cancer cells/tumor were distinguished with high-contrast from normal ones by laser confocal fluorescence imaging,and the tumor-to-normal(T/N)ratios obtained exceed the clinically acceptable threshold of 2.0.Moreover,its capability of in vivo imaging tumor was also demon-strated.These results indicate the potential of PyHP as an effective tool in the early clinical diagnosis of cancers.

外文关键词：

Meso-pyridylhydrazone-functionalized pyronineMeso-substituentsTumor-to-normal(T/N)ratiosFluorescent probesHypochlorous acid

作者：

Linfang Wang、Jing Liu、Minghao Ren、Wei Guo

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作者单位：

Department of Chemistry,Changzhi University,Changzhi 046011,China

School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China

基金：

Scientific and Technological Innovation Program of Colleges and Universities in Shanxi ProvinceScientific and Technological Innovation Program of Colleges and Universities in Shanxi ProvinceFund for Shanxi"1331 Project"

项目编号：

2021L5292021L530

出版年：

2024

DOI：

10.1016/j.cclet.2023.108945

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(6)

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